EndoCompass project: research roadmap for calcium and bone endocrinology

Jähn-Rickert, K.; Tomsic, K.Z.; Anastasilakis, A.D.; Bertocchio, J.P.; Brandi, M.L.; Fassnacht, M.; ... ; Kamenicky, P. (2025)

Article / Letter to editor

Background

Endocrine science remains underrepresented in European Union research programmes despite the fundamental role of hormone health in human well-being. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritization. At national funding level, endocrine societies report limited or little attention of national research funding towards endocrinology. The EndoCompass project-a joint initiative between the European Society of Endocrinology and the European Society of Paediatric Endocrinology-aimed to identify and promote strategic research priorities in endocrine science to address critical hormone-related health challenges.

Methods

Research priorities were established through comprehensive analysis of the EU CORDIS database covering the Horizon 2020 framework period (2014-2020). Expert consultation in bone and calcium endocrinology was conducted to identify key research priorities, followed by broader stakeholder engagement including society members and patient advocacy groups.

Results

Research priorities encompass primary hyperparathyroidism, chronic hypoparathyroidism, and rare calcium-phosphate disorders. Key areas include bone as endocrine organ, bone mass acquisition, secondary osteoporosis, and skeletal dysplasias. Special emphasis is placed on cellular senescence, sex-specific differences in disease manifestation, and development of novel diagnostic tools for bone quality assessment.

Conclusions

This component of the EndoCompass project provides an evidence-based roadmap for strategic research investment. This framework identifies crucial investigation areas into metabolic bone disease pathophysiology, prevention, and treatment strategies, ultimately aimed at reducing the burden of these disorders on individuals and society. The findings support the broader EndoCompass objective of aligning research funding with areas of highest potential impact in endocrine health.

• calcium
• phosphate
• parathyroid hormone
• vitamin D
• bone
• primary hyperparathyroidism
• hypoparathyroidism
• hypophosphataemia
• inactivating PTH/PTHrP signalling disorders
• bone mass acquisition
• bone mineralization
• skeletal dysplasia
• cellular senescence
• diagnostic technologies
• bone quality
• osteocytes
• osteoporosis
• targeted treatments

• All authors: Jähn-Rickert, K.; Tomsic, K.Z.; Anastasilakis, A.D.; Bertocchio, J.P.; Brandi, M.L.; Fassnacht, M.; Cheung, M.S.M.; Gevers, E.; Gittoes, N.; Mäkitie, O.; Martos-Moreno, G.A.; Milovanovic, P.; Raimann, A.; Tencerova, M.; Tsourdi, E.; Vlug, A.G.; Högler, W.; Kamenicky, P.
• Date: 2025-10-01
• Journal: European journal of endocrinology
• Volume: 193
• Pages: ii23 - ii34
• DOI: doi:10.1093/ejendo/lvaf064