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Immunosuppression in older kidney transplant recipients
Key Points
Low-dose tacrolimus, everolimus, and prednisolone did not result in a higher rate of successful transplantation in older kidney transplant recipients.Low-dose tacrolimus, everolimus, and prednisolone did not result in better kidney function or fewer infections in older kidney transplant recipients.
Background
We hypothesized that older kidney transplant recipients receiving low-dose tacrolimus, everolimus, and prednisolone (TEP) have better outcomes than patients receiving standard-dose tacrolimus, mycophenolate mofetil, and prednisolone (TMP).MethodsThe OPTIMIZE study was a randomized clinical trial in kidney transplant recipients age >= 65 years. Patients receiving a kidney from a deceased donor older than 65 years (stratum A), or a kidney from a deceased donor younger than 65 years or a living donor (stratum B) were included. Patients were randomized to TEP or TMP groups. Tacrolimus target trough levels in the TEP group were 5-7 ng/ml...
Show moreKey Points
Low-dose tacrolimus, everolimus, and prednisolone did not result in a higher rate of successful transplantation in older kidney transplant recipients.Low-dose tacrolimus, everolimus, and prednisolone did not result in better kidney function or fewer infections in older kidney transplant recipients.
Background
We hypothesized that older kidney transplant recipients receiving low-dose tacrolimus, everolimus, and prednisolone (TEP) have better outcomes than patients receiving standard-dose tacrolimus, mycophenolate mofetil, and prednisolone (TMP).MethodsThe OPTIMIZE study was a randomized clinical trial in kidney transplant recipients age >= 65 years. Patients receiving a kidney from a deceased donor older than 65 years (stratum A), or a kidney from a deceased donor younger than 65 years or a living donor (stratum B) were included. Patients were randomized to TEP or TMP groups. Tacrolimus target trough levels in the TEP group were 5-7 ng/ml until 3 months, 2-4 ng/ml from 3 to 6 months, and 1.5-4 ng/ml from 6 months onwards. Tacrolimus target trough levels in the TMP group were 8-12, 6-10, and 5-8 ng/ml. Everolimus target trough levels were 3-6 mu g/L. The primary end point of successful transplantation was defined as being alive with a functioning graft with an eGFR above a predefined threshold at 2 years after transplantation. Predefined eGFR thresholds were 30 (stratum A) or 45 ml/min per 1.73 m2 (stratum B).
Results
A total of 379 patients were randomized, of whom 198 were in stratum A (TEP 97, TMP 101) and 181 in stratum B (TEP 90, TMP 91). The median trough levels for everolimus and tacrolimus were within the target range throughout the study. There was no statistically significant difference in successful transplantation at 2 years between the groups (TEP 94 [50%], TMP 110 [57%]; difference 7% [95% confidence interval, -17 to 3] P = 0.91). Regarding the predefined secondary outcomes, patient survival (TEP 167 [89%], TMP 171 [89%]; P = 0.95) and graft survival (TEP 155 [83%], TMP 162 [84%]; P = 0.65) did not differ significantly. Within strata A and B, there were no significant differences in the end points.
Conclusions
Immunosuppression with low-dose tacrolimus, everolimus, and prednisolone did not result in a higher rate of successful transplantation in de novo older kidney transplant recipients compared with immunosuppression with standard-dose TMP.Clinical Trial registry name and registration number:ClinicalTrials.gov, NCT03797196.
- All authors
- Sanders, J.S.F.; Boer, S.E. de; Jonker, J.; Bemelman, F.J.; Betjes, M.G.H.; Vries, A.P.J. de; Hilbrands, L.; Hilhorst, M.; Kuypers, D.R.J.; Vart, P.; Zuilen, A.D. van; Hesselink, D.A.; Berger, S.P.
- Date
- 2025-11-07