Quality of life 1 year after uterine artery embolization vs hysterectomy for symptomatic adenomyosis (QUESTA study)

Trommelen, L.M.; Semmler, A.; Bruijn, A.M. de; Harmsen, M.; Smink, M.; Janssen, P.F.; ... ; Hehenkamp, W.J.K. (2025)

Article / Letter to editor

Introduction: Uterine artery embolization (UAE) is a less-invasive alternative for hysterectomy in therapy-resistant symptomatic adenomyosis. Comparative data are lacking. Our objective is to evaluate the non-inferiority of UAE compared with hysterectomy in improving health-related quality of life (HRQOL) for symptomatic adenomyosis, 1 year post-treatment.

Material and Methods: This multicenter randomized controlled trial was converted into a prospective cohort study. It was prospectively registered at 27-07-2015 (NL-OMON55436, ). From November 2015 to March 2022 participants with symptomatic adenomyosis eligible for hysterectomy were included and offered UAE as an alternative treatment. Primary endpoint was difference in 1-year HRQOL scores between UAE and hysterectomy, using WHO-QOL-Bref and SF-12. Non-inferiority margin was set at five points. Secondary endpoints: WHO-QOL-100 facets "Pain and Discomfort" and "Sexual Activity", adenomyosis-related symptoms, and satisfaction. Multivariable linear mixed models were used. All outcomes were analyzed in the per-protocol population, and repeated in the intention-to-treat population.

Results: Of 101 participants, 51 chose hysterectomy and 50 UAE. Both treatment groups were comparable at baseline, except for employment status, dysmenorrhea score, uterine volume, hemoglobin and CA125 (all adjusted for). Both treatments led to a significant increase in all HRQOL scores after 1 year. The effect differences between UAE and hysterectomy on all HRQOL domains in the per-protocol population were: SF-12 physical beta -4.20, (95% CI -9.53 to 1.12), SF-12 mental beta -4.95 (95% CI -10.83 to 0.94); WHO-QOL-Bref physical beta -7.42 (95% CI -18.51 to 3.68), psychological beta -4.28 (95% CI -13.30 to 4.74), social relations beta -2.23 (95% CI -13.09 to 8.63) and environment beta 0.35 (95% CI -8.39 to 9.09). Non-inferiority of UAE was not demonstrated within the predefined margin. Both hysterectomy and UAE improved "Pain and Discomfort" and "Sexual Activity", with greater effect on pain after hysterectomy (beta 17.17, 95% CI 4.94 to 29.41, p = 0.007). More participants were satisfied after hysterectomy (95%) than after UAE (73%).

Conclusions: Both UAE and hysterectomy significantly increased HRQOL for symptomatic adenomyosis. Neither non-inferiority nor inferiority of UAE could be established. One-year HRQOL scores were comparable; some secondary outcomes were in favor of hysterectomy. UAE is a valid less-invasive alternative to hysterectomy, with preservation of the uterus. Hysterectomy remains the treatment of choice for patients seeking a definite solution.

• adenomyosis
• hysterectomy
• quality of life
• uterine artery embolization

• All authors: Trommelen, L.M.; Semmler, A.; Bruijn, A.M. de; Harmsen, M.; Smink, M.; Janssen, P.F.; Rooij, I. van; Bavel, J. van; Geomini, P.; Maas, J.W.M.; Radder, C.M.; Kesteren, P. van; Kwee, J.; Bakkum, E.; Lange, M. de; Leeuw, R.A. de; Groenman, F.; Mijatovic, V.; Timmermans, A.; Lely, R.; Lamers, A.; Vos, D.; Hoecke, G. van; Elgersma, O.; Vliet, H.A.A.M. van; Yo, L.S.F.; Twijnstra, A.R.H.; Jansen, F.W.; Rijswijk, C.S.P. van; Kruimer, H.; Tseng, C.M.E.S.N.; Coppus, S.; Arntz, M.; Wust, A.F.J.; Blomjous, J.G.A.M.; L. van boven; Venmans, A.; Twisk, J.W.R.; Huirne, J.A.F.; Lohle, P.N.M.; Hehenkamp, W.J.K.
• Date: 2025-05-26
• Journal: Acta Obstetricia et Gynecologica Scandinavica
• Volume: 104
• Issue: 8
• Pages: 1558 - 1574
• DOI: doi:10.1111/aogs.15165