Exploring kidney organoid vascularization

Koning, M. (2026)

Doctoral Thesis

Kidney organoids generated from human induced pluripotent stem cells resemble human kidney tissue to a certain degree. However, they lack a functional vasculature and remain immature. This thesis explores the process of kidney organoid vascularization and its effect on organoid development and maturation.

• Kidney
• Organoid
• Induced pluripotent stem cells
• Endothelial cells
• Vascularization

• All authors: Koning, M.
• Supervisor: Rabelink, A.J.
• Co-supervisor: Berg, C.W. van den
• Committee: Geijsen, N.; Peters, D.J.M.; Orlova, V.; Jaffredo, T.; Carmeliet, P.
• Qualification: Doctor (dr.)
• Awarding Institution: Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
• Date: 2026-02-04
• ISBN (print): 9789465229782
• DOI: doi:10.60602/1887-4288745