Identification of therapeutic targets and antisense oligonucleotide mediated exon skipping based therapies in arthritis

Elis, A.S. (2016)

Doctoral Thesis

Rheumatoid arthritis (RA) is a chronic inflammatory joint disease leading to
destruction of cartilage and bone. The inflammation in the joints is mainly caused by
inflammatory cytokines that are over-produced by various types of immune cells.
Artritis is an autoimmune disease that is characterized by the presence of
autoantibodies. These autoantibodies form immune complexes (IC) which are other
important players in joint inflammation because they activate various immune cells by
binding to Fc receptors (FcR). Binding and activation of FcRs initiates
intracellular signaling that triggers activation and release of various inflammatory
mediators. In this thesis we describe a variety of aspects of arthritis research that has
been performed to get a better understanding of the underlying molecular and cellular
disease mechanisms and to develop novel therapeutic strategies.

• Rheumatoid arthritis
• Inflammatory cytokines
• Fcg receptors
• Antisense oligonucleotides
• Exon skipping

• All authors: Elis, A.S.
• Supervisor: Ommen, G.J. van
• Co-supervisor: Verbeek, J.S.
• Committee: Yazdanbakhsh, M.; Voorberg, J.J.; Daha, M.R.; Dunnen, J. den; Lubberts, E.; Hamann, J.; Hoen, P.B. 't
• Qualification: Doctor (dr.)
• Awarding Institution: Medicine, Leiden University Medical Center (LUMC), Leiden University
• Date: 2016-06-29
• ISBN (print): 97890825532