Leiden University Scholarly Publications

Persistent URL of this record https://hdl.handle.net/1887/4082969

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    • Chapter 1
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    • Chapter 3
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    • Chapter 4
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    • Chapter 5
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    • Chapter 6
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    • Chapter 7: Summary in English
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    • Summary in Dutch
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Huizenga, M.C.W. (2024)

MAGL modulators: structure-guided optimisation and characterisation

Doctoral Thesis
The aim of the research described in this thesis was to use structure-based design to optimise multiple properties of aryl sulfoxide monoacylglycerol lipase inhibitors as anti-inflammatory analgesics.
Medicinal chemistry
Endocannabinoid system
Structure-guided drug design
PROTACs
All authors
Huizenga, M.C.W.
Supervisor
Stelt, M. van der
Co-supervisor
Janssen, A.P.A.; Berg, R.J.B.H.N. van den
Committee
Kasteren, S.I. van; Ubbink, M.; Perrakis, A.; Heitman, L.H.; Nazaré, M.; Dekker, F.J.
Qualification
Doctor (dr.)
Awarding Institution
LIC/CB/Molecular Physiology, Wiskunde en Natuurwetenschappen, Leiden University
Date
2024-09-10
ISBN (print)
9789465061665

Funding

Sponsorship
Oncode Institute