Small Amounts of Sub-Visible Aggregates Enhance the Immunogenic Potential of Monoclonal Antibody Therapeutics

Ahmadi, M.; Bryson, C.J.; Cloake, E.A.; Welch, K.; Filipe, V.; Romeijn, S.G.; ... ; Fogg, M.H. (2015)

Article / Letter to editor

• anti-drug antibodies
• biotherapeutics
• CD4(+) T cell responses
• humanized antibodies
• immunogenicity

• All authors: Ahmadi, M.; Bryson, C.J.; Cloake, E.A.; Welch, K.; Filipe, V.; Romeijn, S.G.; Hawe, A.; Jiskoot, W.; Baker, M.P.; Fogg, M.H.
• Date: 2015-04-30
• Journal: PHARMACEUTICAL RESEARCH
• Volume: 32
• Issue: 4
• Pages: 1383 - 1394
• DOI: doi:10.1007/s11095-014-1541-x