Leiden University Scholarly Publications

Persistent URL of this record https://hdl.handle.net/1887/3765914

In Collections

This item can be found in the following collections:

He, Y. (2024)

Nanoparticle-based combination drug delivery systems for effective cancer treatment

Doctoral Thesis
Our research focuses on developing advanced nanoparticles for cancer treatment, with a focus on reducing side effects and improving efficacy. We have developed nanoparticles that can not only target cancer cells but also serve as imaging agents to monitor treatment. In addition, we have investigated how lipids and immune cells in the tumor environment can be manipulated to improve cancer therapy.
Our findings show that the developed nanoparticles can improve drug delivery to tumors while reducing side effects to the rest of the body. Moreover, we have shown that lipids can be used to reprogramme immune cells in the tumor environment, causing them to exhibit anti-tumor activity. In addition, the nanoparticles show excellent delivery capabilities in 3D models of skin cancer, allowing them to kill skin tumor cells more effectively. The societal relevance of our research lies in improving cancer treatment options, particularly by reducing side effects and increasing the...Show moreOur research focuses on developing advanced nanoparticles for cancer treatment, with a focus on reducing side effects and improving efficacy. We have developed nanoparticles that can not only target cancer cells but also serve as imaging agents to monitor treatment. In addition, we have investigated how lipids and immune cells in the tumor environment can be manipulated to improve cancer therapy.
Our findings show that the developed nanoparticles can improve drug delivery to tumors while reducing side effects to the rest of the body. Moreover, we have shown that lipids can be used to reprogramme immune cells in the tumor environment, causing them to exhibit anti-tumor activity. In addition, the nanoparticles show excellent delivery capabilities in 3D models of skin cancer, allowing them to kill skin tumor cells more effectively. The societal relevance of our research lies in improving cancer treatment options, particularly by reducing side effects and increasing the effectiveness of therapies. These findings provide new insights and approaches for the development of cancer therapies, which can contribute to a better quality of life for patients.
We have achieved these results through a multidisciplinary approach using nanotechnology, chemotherapeutic drugs and knowledge of the tumor environment. Our findings are special because they offer promising new strategies for cancer treatment using cutting-edge technologies and insights into tumor biology.Show less
Cancer
PLGA-Nanoparticles
Rare-earth doped Nanoparticles
Lipids
Tumor microenvironment immune modulation
Tumor immuno-chemotherapy
Drug delivery
Full-thickness model
All authors
He, Y.
Supervisor
Buchem, M.A. van
Co-supervisor
Eich, C.
Committee
Dijke, P. ten; Neefjes, J.J.C.; Gelder, T. van; Ghalbzouri, A. el; Djanashvili, K.
Qualification
Doctor (dr.)
Awarding Institution
Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
Date
2024-06-25
ISBN (print)
9789465061078

Funding

Sponsorship
H2020-MSCA-RISE grant number 777682-CANCER and 872860-PRISAR2