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Lifestyle and incident dementia: a COSMIC individual participant data meta-analysis
INTRODUCTION
The LIfestyle for BRAin Health (LIBRA) index yields a dementia risk score based on modifiable lifestyle factors and is validated in Western samples. We investigated whether the association between LIBRA scores and incident dementia is moderated by geographical location or sociodemographic characteristics.
METHODS
We combined data from 21 prospective cohorts across six continents (N = 31,680) and conducted cohort-specific Cox proportional hazard regression analyses in a two-step individual participant data meta-analysis.
RESULTS
A one-standard-deviation increase in LIBRA score was associated with a 21% higher risk for dementia. The association was stronger for Asian cohorts compared to European cohorts, and for individuals aged ≤75 years (vs older), though only within the first 5 years of follow-up. No interactions with sex, education, or socioeconomic position were observed.
DISCUSSION
Modifiable risk and...
Show moreINTRODUCTION
The LIfestyle for BRAin Health (LIBRA) index yields a dementia risk score based on modifiable lifestyle factors and is validated in Western samples. We investigated whether the association between LIBRA scores and incident dementia is moderated by geographical location or sociodemographic characteristics.
METHODS
We combined data from 21 prospective cohorts across six continents (N = 31,680) and conducted cohort-specific Cox proportional hazard regression analyses in a two-step individual participant data meta-analysis.
RESULTS
A one-standard-deviation increase in LIBRA score was associated with a 21% higher risk for dementia. The association was stronger for Asian cohorts compared to European cohorts, and for individuals aged ≤75 years (vs older), though only within the first 5 years of follow-up. No interactions with sex, education, or socioeconomic position were observed.
DISCUSSION
Modifiable risk and protective factors appear relevant for dementia risk reduction across diverse geographical and sociodemographic groups.
Show less- All authors
- Asbroeck, S. van; Köhler, S.; Boxtel, M.P.J. van; Lipnicki, D.M.; Crawford, J.D.; Castro-Costa, E.; Lima-Costa, M.F.; Blay, S.L.; Xiao, S.F.; Wang, T.; Yue, L.; Lipton, R.B.; Katz, M.J.; Derby, C.A.; Guerchet, M.; Preux, P.M.; Mbelesso, P.; Norton, J.; Ritchie, K.; Skoog, I.; Najar, J.; Sterner, T.R.; Scarmeas, N.; Yannakoulia, M.; Dardiotis, T.; Rolandi, E.; Davin, A.; Rossi, M.; Gureje, O.; Ojagbemi, A.; Bello, T.; Kim, K.W.; Han, J.W.; Oh, D.J.; Trompet, S.; Gussekloo, J.; Riedel-Heller, S.G.; Röhr, S.; Pabst, A.; Shahar, S.; Rivan, N.F.M.; Singh, D.K.A.; Jacobsen, E.; Ganguli, M.; Hughes, T.; Haan, M.; Aiello, A.E.; Ding, D.; Zhao, Q.H.; Xiao, Z.X.; Narazaki, K.; Chen, T.; Chen, S.M.; Ng, T.P.; Gwee, X.; Gao, Q.; Brodaty, H.; Trollor, J.; Kochan, N.; Lobo, A.; Santabárbara, J.; Gracia-Garcia, P.; Sachdev, P.S.; Deckers, K.; Cohort Studies Memory Int Consorti
- Date
- 2024-04-27
- Volume
- 20
- Issue
- 6
- Pages
- 3972 - 3986