Leiden University Scholarly Publications

Persistent URL of this record https://hdl.handle.net/1887/3750362

Documents

In Collections

This item can be found in the following collections:

Oevelen, M. van; Bonenkamp, A.A.; Sluijs, A.V. van der; Bos, W.J.W.; Douma, C.E.; Buren, M. van; ... ; DOMESTICO Study Grp (2023)

Health-related quality of life and symptom burden in patients on haemodialysis

Article / Letter to editor
Background. Patients on haemodialysis (HD) generally experience poor health-related quality of life (HRQoL) and a broad range of physical and mental symptoms, but it is unknown whether this differs between younger and older patients. We aimed to describe the trajectories of HRQoL and symptom burden of patients <70 and >= 70 years old and to assess the impact of symptom burden on HRQoL.Methods. In incident Dutch HD patients, HRQoL and symptoms were measured with the 12-item Short Form Health Survey and Dialysis Symptom Index. We used linear mixed models for examining the trajectories of HRQoL and symptom burden during the first year of dialysis and linear regression for the impact of symptom burden on HRQoL.Results. In 774 patients, the trajectories of physical HRQoL, mental HRQoL and symptom burden were stable during the first year of dialysis. Compared with patients <70 years of age, patients >= 70 years reported similar physical HRQoL {mean difference -0.61 [95% confidence...Show moreBackground. Patients on haemodialysis (HD) generally experience poor health-related quality of life (HRQoL) and a broad range of physical and mental symptoms, but it is unknown whether this differs between younger and older patients. We aimed to describe the trajectories of HRQoL and symptom burden of patients <70 and >= 70 years old and to assess the impact of symptom burden on HRQoL.Methods. In incident Dutch HD patients, HRQoL and symptoms were measured with the 12-item Short Form Health Survey and Dialysis Symptom Index. We used linear mixed models for examining the trajectories of HRQoL and symptom burden during the first year of dialysis and linear regression for the impact of symptom burden on HRQoL.Results. In 774 patients, the trajectories of physical HRQoL, mental HRQoL and symptom burden were stable during the first year of dialysis. Compared with patients <70 years of age, patients >= 70 years reported similar physical HRQoL {mean difference -0.61 [95% confidence interval (CI) -1.86-0.63]}, better mental HRQoL [1.77 (95% CI 0.54-3.01)] and lower symptom burden [-2.38 (95% CI -5.080.32)]. With increasing symptom burden, physical HRQoL declined more in older than in younger patients (beta= -0.287 versus -0.189, respectively; P-value for interaction =.007). For mental HRQoL, this decrease was similar in both age groups (beta = -0.295 versus -0.288, P =.847).Conclusion. Older HD patients generally experience a better mental HRQoL and a (non-statistically significant) lower symptom burden compared with younger patients. Their physical HRQoL declines more rapidly with increasing symptom burden.Show less
ageing
dialysis
end-stage renal disease
kidney failure
patient-reported outcomes
All authors
Oevelen, M. van; Bonenkamp, A.A.; Sluijs, A.V. van der; Bos, W.J.W.; Douma, C.E.; Buren, M. van; Meuleman, Y.; Dekker, F.W.; Jaarsveld, B.C. van; Abrahams, A.C.; DOMESTICO Study Grp
Date
2023-08-14
Journal
Nephrology Dialysis Transplantation
Volume
39
Issue
3
Pages
436 - 444
DOI
doi:10.1093/ndt/gfad179
Link
https://academic.oup.com/ndt/article/39/3/436/7242560