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Haas, M.; Mirocha, J.; Amann, K.; Bajema, I.M.; Barisoni, L.; Becker, J.U.; ... ; Seshan, S.V. (2021)

Impact of consensus definitions on identification of glomerular lesions by light and electron microscopy

Article / Letter to editor
Introduction: In 2020, a working group of 13 renal pathologists published consensus definitions for 47 individual glomerular lesions found on light microscopy (LM) and 47 glomerular lesions and 9 normal structures found on electron microscopy (EM).Methods: To test the impact of these definitions on identification of these lesions and structures, 2 surveys were circulated to all members of the Renal Pathology Society (RPS), each having 32 images (19 LM, 13 EM) and accompanying questions with 5 multiple-choice answers, one being the consensus choice of the working group. The first survey (survey 1 [S1]), answered by 297 RPS members, was sent in September 2020, before publication of the consensus definitions. The second (survey 2 (S2]), with images of the same lesions and structures (but not the same images) and the same questions and multiple choices in different order, was sent in April 2020, 5 months after the publication of the definitions.Results: S2 was taken by 181 RPS members;...Show moreIntroduction: In 2020, a working group of 13 renal pathologists published consensus definitions for 47 individual glomerular lesions found on light microscopy (LM) and 47 glomerular lesions and 9 normal structures found on electron microscopy (EM).Methods: To test the impact of these definitions on identification of these lesions and structures, 2 surveys were circulated to all members of the Renal Pathology Society (RPS), each having 32 images (19 LM, 13 EM) and accompanying questions with 5 multiple-choice answers, one being the consensus choice of the working group. The first survey (survey 1 [S1]), answered by 297 RPS members, was sent in September 2020, before publication of the consensus definitions. The second (survey 2 (S2]), with images of the same lesions and structures (but not the same images) and the same questions and multiple choices in different order, was sent in April 2020, 5 months after the publication of the definitions.Results: S2 was taken by 181 RPS members; 64% also took 51 and 61% reported having read the definitions paper (def. paper). Mean agreement with the consensus answers increased modestly between the 2 surveys (65.2% vs. 72.0%, P = 0.097); the increase was greater and significant when only respondents to S2 who read the def. paper were considered (65.2% vs. 74.8%, P = 0.026). Furthermore, in S2 agreement with consensus answers was greater among respondents who read this paper versus those who did not (66.9% vs. 74.8%, P < 0.0001).Conclusions: Publication of the consensus definitions modestly improved interobserver agreement in identification of glomerular lesions.Show less
electron microscopy
glomerulonephritis
glomerulus
kidney biopsy
renal pathology
All authors
Haas, M.; Mirocha, J.; Amann, K.; Bajema, I.M.; Barisoni, L.; Becker, J.U.; Jennette, J.C.; Joh, K.; Ljubanovic, D.G.; Roberts, I.S.D.; Roelofs, J.J.; Sethi, S.; Suarez, R.; Zeng, C.H.; Seshan, S.V.
Date
2021-12-28
Journal
Kidney International Reports
Volume
7
Issue
1
Pages
78 - 86
DOI
doi:10.1016/j.ekir.2021.10.014