MR vascular fingerprinting with hybrid gradient-spin echo dynamic susceptibility contrast MRI for characterization of microvasculature in gliomas

Venugopal, K.; Arzanforoosh, F.; Dorth, D. van; Smits, M.; Osch, M.J.P. van; Hernandez-Tamames, J.A.; Warnert, E.A.H.; Poot, D.H.J.

doi:doi:10.3390/cancers15072180

Persistent URL of this record https://hdl.handle.net/1887/3748097

View statistics

In Collections

This item can be found in the following collections:

Scholarly Publications

Venugopal, K.; Arzanforoosh, F.; Dorth, D. van; Smits, M.; Osch, M.J.P. van; Hernandez-Tamames, J.A.; ... ; Poot, D.H.J. (2023)

MR vascular fingerprinting with hybrid gradient-spin echo dynamic susceptibility contrast MRI for characterization of microvasculature in gliomas

Article / Letter to editor

Characterization of tumor microvasculature is important in tumor assessment and studying treatment response. This is possible by acquiring vascular biomarkers with magnetic resonance imaging (MRI) based on dynamic susceptibility contrast (DSC). We propose magnetic resonance vascular fingerprinting (MRVF) for hybrid echo planar imaging (HEPI) acquired during the first passage of the contrast agent (CA). The proposed approach was evaluated in patients with gliomas, and we simultaneously estimated vessel radius and relative cerebral blood volume. These parameters were also compared to the respective values estimated using the previously introduced vessel size imaging (VSI) technique. The results of both methods were found to be consistent. MRVF was also found to be robust to noise in the estimation of the parameters. DSC-HEPI-based MRVF provides characterization of microvasculature in gliomas with a short acquisition time and can be further improved in several ways to increase our...Show more Characterization of tumor microvasculature is important in tumor assessment and studying treatment response. This is possible by acquiring vascular biomarkers with magnetic resonance imaging (MRI) based on dynamic susceptibility contrast (DSC). We propose magnetic resonance vascular fingerprinting (MRVF) for hybrid echo planar imaging (HEPI) acquired during the first passage of the contrast agent (CA). The proposed approach was evaluated in patients with gliomas, and we simultaneously estimated vessel radius and relative cerebral blood volume. These parameters were also compared to the respective values estimated using the previously introduced vessel size imaging (VSI) technique. The results of both methods were found to be consistent. MRVF was also found to be robust to noise in the estimation of the parameters. DSC-HEPI-based MRVF provides characterization of microvasculature in gliomas with a short acquisition time and can be further improved in several ways to increase our understanding of tumor physiology.
Show less

MR vascular fingerprinting

dynamic susceptibility contrast imaging

glioma

vascular biomarkers

vessel radius

cerebral blood volume

vessel size imaging