p Factor V Leiden but not the factor II 20210G>A mutation is a risk factor for premature coronary artery disease: a case-control study in Iran

Agosti, P.; Mancini, I.; Sadeghian, S.; Pagliari, M.T.; Abbasi, S.H.; Pourhosseini, H.; ... ; Peyvandi, F. (2023)

Article / Letter to editor

Background: Factor V Leiden (FVL) and factor II c.*97G>A (rs1799963) are genetic risk factors for venous thromboembolism. Their contribution to coronary artery disease (CAD) is less clear. Objectives: This study aimed to investigate the association between FVL, rs1799963, and premature CAD in Iranians.Methods: We performed a genetic case-control study of 944 cases and 1081 controls from the premature CAD Milano-Iran study, including patients aged 18-55 (female) and 18-45 years (male) who underwent coronary angiography at the Tehran Heart Centre (Iran) in 2004-2011. Cases had luminal stenosis & GE;50% in at least 1 main coronary ar-tery or branch. Controls were age-and sex-matched with no CAD history. FVL and rs1799963 were genotyped using TaqMan SNP genotyping assays. Association was tested by logistic regression adjusted for matching factors and ethnicity. Effect modi-fication by sex and cardiovascular risk factors (metabolic [obesity, hypertension, hyperlipidemia, and diabetes], and smoking) was assessed.Results: The risk of premature CAD was increased by 50% in FVL carriers (adjusted odds ratio [adjOR] 1.54 [95% CI, 0.95-2.48]) and slightly reduced in rs1799963 carriers (adjOR 0.71 [95% CI, 0.40-1.27]). These effects were more pronounced in women than men (FVL, adjOR 1.66 vs 1.25; rs1799963, adjOR 0.60 vs 1.07). The risk of premature CAD was substantially increased in carriers of FVL with at least 1 metabolic risk factor compared with noncarriers without metabolic risk factors (adjOR 25.14 [95% CI, 12.51-50.52]).Conclusion: FVL but not FII rs1799963 was associated with an increased risk of CAD in young Iranians. This risk increased considerably when combined with metabolic car-diovascular risk factors.

• coronary artery disease
• factor V Leiden
• factor II
• hypercoagulability
• myocardial infarction

• All authors: Agosti, P.; Mancini, I.; Sadeghian, S.; Pagliari, M.T.; Abbasi, S.H.; Pourhosseini, H.; Boroumand, M.; Lotfi-Tokaldany, M.; Pappalardo, E.; Maino, A.; Rosendaal, F.R.; Peyvandi, F.
• Date: 2023-02-01
• Journal: Research and Practice in Thrombosis and Haemostasis
• Volume: 7
• Issue: 1
• DOI: doi:10.1016/j.rpth.2023.100048
• Link: https://www.sciencedirect.com/science/article/pii/S2475037923000134?via%...