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Juffermans, J.F.; Westenberg, J.J.M.; Boogaard, P.J. van den; Lamb, H.J. (2023)

Effects of ageing on aortic hemodynamics measured by 4D-flow MRI: a case series

Article / Letter to editor
Background It has been demonstrated that the rate of aortic dilatation is influenced by alteration of aortic hemodynamics, such as normalized flow displacement (FDN) and wall shear stress (WSS). However, the effects of ageing on aortic hemodynamics have not yet been described. Case summary 4D-Flow MRI derived aorta hemodynamics were derived in the ascending aorta of a patient with ascending aortic aneurysm (mean +/- standard deviation: 46 +/- 1 mm) and a healthy volunteer (aortic diameter 30 +/- 1 mm) with long-term follow-up of ten and eight years, respectively. At all timepoints, compared to the healthy volunteer, the patient demonstrated higher magnitudes of FDN (7% +/- 1% vs. 3% +/- 1%) and WSS angle (36 degrees +/- 3 degrees vs. 24 degrees +/- 6 degrees), and lower WSS magnitude (565 +/- 100 mPa vs. 910 +/- 115 mPa), axial WSS (426 +/- 71 mPa vs. 800 +/- 108 mPa) and circumferential WSS (297 +/- 64 mPa vs. 340 +/- 85 mPa). The patient and healthy volunteer demonstrated...Show moreBackground It has been demonstrated that the rate of aortic dilatation is influenced by alteration of aortic hemodynamics, such as normalized flow displacement (FDN) and wall shear stress (WSS). However, the effects of ageing on aortic hemodynamics have not yet been described. Case summary 4D-Flow MRI derived aorta hemodynamics were derived in the ascending aorta of a patient with ascending aortic aneurysm (mean +/- standard deviation: 46 +/- 1 mm) and a healthy volunteer (aortic diameter 30 +/- 1 mm) with long-term follow-up of ten and eight years, respectively. At all timepoints, compared to the healthy volunteer, the patient demonstrated higher magnitudes of FDN (7% +/- 1% vs. 3% +/- 1%) and WSS angle (36 degrees +/- 3 degrees vs. 24 degrees +/- 6 degrees), and lower WSS magnitude (565 +/- 100 mPa vs. 910 +/- 115 mPa), axial WSS (426 +/- 71 mPa vs. 800 +/- 108 mPa) and circumferential WSS (297 +/- 64 mPa vs. 340 +/- 85 mPa). The patient and healthy volunteer demonstrated different aortic dilatation rates (regression slope +/- standard error: 0.2 +/- 0.1 vs. 0.1 +/- 0.2 mm per year) and trends in FDN (0.1% +/- 0.1% vs. 0.1% +/- 0.2% per year), WSS magnitude (22 +/- 9 vs. 35 +/- 13 mPa per year), axial WSS (19 +/- 4 vs. 37 +/- 7 mPa per year), circumferential WSS (9 +/- 8 vs. 5 +/- 15 mPa per year), and WSS angle (-0.5 degrees +/- 0.4 degrees vs. -0.8 degrees +/- 1.0 degrees per year). Discussion Aortic hemodynamic parameters are marginally affected by ageing and the aortic diameter in this case series. Since aortic hemodynamic parameters have been associated with aortic dilation by previous studies, the outcomes of the two subjects suggest that the aortic dilatation rate will remain constant while individuals are ageing and dilating.Show less
Aorta
Aortic ageing
Hemodynamics
Aneurysms
4D-flow MRI
Case series
All authors
Juffermans, J.F.; Westenberg, J.J.M.; Boogaard, P.J. van den; Lamb, H.J.
Date
2023-04-10
Journal
European Heart Journal: Case Reports
Volume
7
Issue
4
DOI
doi:10.1093/ehjcr/ytad130
Link
https://academic.oup.com/ehjcr/article/7/4/ytad130/7111605