Ellipro scores of donor epitope specific HLA antibodies are not associated with kidney graft survival

Kardol-Hoefnagel, T.; Senejohnny, D.M.; Kamburova, E.G.; Wisse, B.W.; Gruijters, M.L.; Joosten, I.; ... ; Otten, H.G. (2024)

Article / Letter to editor

In kidney transplantation, donor HLA antibodies are a risk factor for graft loss. Accessibility of donor eplets for HLA antibodies is predicted by the ElliPro score. The clinical usefulness of those scores in relation to transplant outcome is unknown. In a large Dutch kidney transplant cohort, Ellipro scores of pretransplant donor antibodies that can be assigned to known eplets (donor epitope specific HLA antibodies [DESAs]) were compared between early graft failure and long surviving deceased donor transplants. We did not observe a significant Ellipro score difference between the two cohorts, nor significant differences in graft survival between transplants with DESAs having high versus low total Ellipro scores. We conclude that Ellipro scores cannot be used to identify DESAs associated with early versus late kidney graft loss in deceased donor transplants.

• DESA
• Ellipro scores
• kidney transplantation

• All authors: Kardol-Hoefnagel, T.; Senejohnny, D.M.; Kamburova, E.G.; Wisse, B.W.; Gruijters, M.L.; Joosten, I.; Allebes, W.A.; Meer, A. van der; Hilbrands, L.B.; Baas, M.C.; Spierings, E.; Hack, C.E.; Reekum, F.E. van; Zuilen, A.D. van; Verhaar, M.C.; Drop, A.C.A.D.; Plaisier, L.; Melchers, R.C.A.; Seelen, M.A.J.; Sanders, J.S.; Hepkema, B.G.; Kroesen, B.J.; Bungener, L.B.; Roozendaal, C.; Tilanus, M.G.J.; Voorter, C.E.; Wieten, L.; Duijnhoven, E.M. van; Gelens, M.A.C.J.; Christiaans, M.H.L.; Ittersum, F.J. van; Nurmohamed, S.A.; Lardy, N.M.; Swelsen, W.; Pant, K.A.M.I. van der; Weerd, N.C. van der; Berge, I.J.M. ten; Hoitsma, A.; Boog, P.J.M. van der; Fijter, J.W. de; Betjes, M.G.H.; Roelen, D.L.; Claas, F.H.; Bemelman, F.J.; Heidt, S.; Otten, H.G.
• Date: 2024-01-01
• Journal: HLA: Immune Response Genetics
• Volume: 103
• Issue: 1
• DOI: doi:10.1111/tan.15297