Treatment course comparison between anxiety-related disorders in adult outpatients: a Leiden routine outcome monitoring study

Carlier, I.V.E.; Elst, L.V. van der; Jong, K. de; Vliet, I.M. van (2023)

Article / Letter to editor

Anxiety-related disorders constitute the leading prevalent mental disorders, with major burden on patients, their relatives, and society. Moreover, there is considerable treatment nonadherence/nonresponse. We used routine outcome monitoring (ROM) data from outpatients covering four anxiety-related disorders (DSM-IV-R, N = 470) to examine their 6-month treatment course and its predictors: generalized anxiety disorder, panic disorder with agoraphobia, obsessive-compulsive disorder, and posttraumatic stress disorder. Measures included Mini-International Neuropsychiatric Interview Plus, Brief Symptom Inventory (BSI), Montgomery-Åsberg Depression Rating Scale (MADRS), Brief Anxiety Scale (BAS), and Short Form Health Survey 36 (SF-36). On the clinician-rated instruments (MADRS/BAS), all anxiety-related disorder groups showed a significant albeit modest improvement after treatment. On the BSI self-rating, only generalized anxiety disorder and posttraumatic stress disorder showed a significant modest improvement. No anxiety-related disorder groups improved significantly regarding SF-36 physical functioning. For BSI symptom course, significant predictors were comorbid somatoform/total disorders, SF-36 physical functioning/general health, and MADRS score. Clinical implications and future research recommendations are discussed.

• Treatment course
• generalized anxiety disorder
• panic disorder with agoraphobia
• obsessive compulsive disorder
• posttraumatic stress disorder

• All authors: Carlier, I.V.E.; Elst, L.V. van der; Jong, K. de; Vliet, I.M. van
• Date: 2023-08-01
• Journal: Journal of Nervous and Mental Disease
• Volume: 211
• Issue: 8
• Pages: 601 - 612
• DOI: doi:10.1097/NMD.0000000000001667
• Link: https://journals.lww.com/jonmd/fulltext/2023/08000/treatment_course_comp...