The appropriateness of cholesterol-lowering medication in old age

Ploeg, M.A. van der (2024)

Doctoral Thesis

Cholesterol-lowering medications aim to prevent cardiovascular events, caused by arteriosclerosis. Older adults (75 years and older) have a high cardiovascular risk based on age alone, and it is estimated that 1 in 3 older adults use cholesterol-lowering medication. The vast majority (96% in the Netherlands) use a statin.
The appropriateness of cholesterol-lowering medication for older adults is under debate.  While there is strong evidence for the benefits of statins in relatively healthy older adults with a history of cardiovascular disease, for other groups the evidence is less convincing. Also, statins are associated with hindering side effects. 

In this thesis, various aspects of the appropriateness of cholesterol-lowering medication for older adults were studied, using different research designs. 

Five recurrent themes were of the utmost importance in the assessment of the appropriateness of cholesterol-lowering medication in older adults; 1) the individual context of a patient, 2) life expectancy, 3) hindering side effects, 4) cardiovascular history, and 5) the complexity of health problems.

Based in these five themes, five key questions were distilled that can be used in a systematic evaluation of the appropriateness of cholesterol- lowering treatment for an individual patient.

• Cholesterol-lowering-medication
• Deprescribing
• Frailty
• Cardiovascular diseases
• Clinical decision-making
• Geriatrics
• Prevention

• All authors: Ploeg, M.A. van der
• Supervisor: Gussekloo, J.
• Co-supervisor: Poortvliet, R.K.E.; Drewes, Y.M.
• Committee: Jukema, J.W.; Peet, P.G. van; Marum, R.J. van; Muller, M.; Streit, S.
• Qualification: Doctor (dr.)
• Awarding Institution: Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
• Date: 2024-02-15
• ISBN (print): 9789463619479
• Sponsorship: ZonMw (The Netherlands Organization for Health Research and Development), research grant number 83912001