Advanced MRI markers of cerebral small vessel disease

Harten, T.W. van (2024)

Doctoral Thesis

The overarching theme throughout this thesis is the exploration of new and the improvement of existing methods of measuring neurovascular pathology using MRI techniques and postprocessing. As cerebrovascular afflictions are not located at a single location, these methods are applied throughout the cerebrovascular tree. This thesis starts with the large (macro) arteries (chapter 2), to the function of (micro) arteries (chapters 3 and 4), to remnants of hemorrhages in brain tissue (chapter 5), to finally the venous compartment (chapter 6), and takes into account both structure and function of selected parts of the cerebrovascular tree.

• Magnetic resonance imaging
• Cerebral small vessel disease
• Cerebral amyloid angiopathy

• All authors: Harten, T.W. van
• Supervisor: Osch, M.J.P. van; Wermer, M.J.H.
• Co-supervisor: Walderveen, M.A.A. van
• Committee: Claassen, J.; Etten, E. van; Hendrikse, J.; Webb, A.
• Qualification: Doctor (dr.)
• Awarding Institution: Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
• Date: 2024-01-31
• ISBN (print): 9789490858834
• Sponsorship: This research has been made possible by the Dutch Heart Foundation and the Netherlands Organisation for Scientific Research (NWO), as part of their joint strategic research programme: "Earlier recognition of cardiovascular diseases”. This project is partially financed by the PPP Allowance made available by Top Sector Life Sciences & Health to the Dutch Heart foundation to stimulate public-private partnerships