Comparing survival after resection of pancreatic cancer with and without pancreatic cysts: nationwide registry-based study

Gorris, M.; Huijgevoort, N.C.M. van; Farina, A.; Brosens, L.A.A.; Santvoort, H.C. van; Koerkamp, B.G.; ... ; Dutch Pancreatic Canc Grp (2022)

Article / Letter to editor

Background: Outcome after resection of pancreatic ductal adenocarcinoma associated with pancreatic cystic neoplasms (PCN-PDAC) might differ from PDAC not associated with PCN. This nationwide, registry-based study aimed to compare the overall survival (OS) in these patients. Methods: Data from consecutive patients after pancreatic resection for PDAC between 2013 and 2018 were matched with the corresponding pathology reports. Primary outcome was OS for PCN-PDAC and PDAC including 1-year and 5-year OS. Cox regression analysis was used to correct for prognostic factors (e.g., pT-stage, pN-stage, and vascular invasion). Results: In total, 1994 patients underwent resection for PDAC including 233 (12%) with PCN-PDAC. Median estimated OS was better in patients with PCN-PDAC (34.5 months [95%CI 25.6 to 43.5]) as compared to PDAC not associated with PCN (18.2 months [95%CI 17.3 to 19.2]; hazard ratio 0.53 [95%CI 0.44–0.63]; p < 0.001). The difference in OS remained after correction for prognostic factors (adjusted hazard ratio 1.58 [95%CI 1.32−1.90]; p < 0.001). Conclusions: This nationwide registry-based study showed that 12% of resected PDAC were PCN-associated. Patients with PCN-PDAC had better OS as compared to PDAC not associated with PCN.

• pancreatic neoplasms
• pancreatic cyst
• surgical oncology
• survival analyses
• Kaplan-Meier estimates

• All authors: Gorris, M.; Huijgevoort, N.C.M. van; Farina, A.; Brosens, L.A.A.; Santvoort, H.C. van; Koerkamp, B.G.; Bruno, M.J.; Besselink, M.G.; Hooft, J.E. van; Dutch Pancreatic Canc Grp
• Date: 2022-09-01
• Journal: Cancers
• Volume: 14
• Issue: 17
• DOI: doi:10.3390/cancers14174228
• Link: https://www.mdpi.com/2072-6694/14/17/4228