Learning to perceive: psychological and neural processes underlying placebo and nocebo effects on cutaneous sensations

Blythe, J.S. (2023)

Doctoral Thesis

Placebo and nocebo effects, positive and negative effects experienced after both real and sham interventions, putatively due to positive or negative outcome expectancies, can shape our sensory experience. Although placebo and nocebo effects are known to occur reliably in many individuals for sensations like pain and itch, our understanding of psychological learning processes and methodological factors that influence these effects remains limited. Chapters 2, 3, and 4 investigate this topic with meta-analysis, narrative review, and a behavioral study. Similarly, our characterization of the neural markers of nocebo effects is incomplete. A better grasp of how these effects form is necessary to contextualize them within the larger framework of bottom-up and top-down integration. Chapters 5, 6, and 7 investigate this topic in a series of EEG and fMRI studies. Advancing both psychological and neural accounts of placebo and nocebo effects will aid in applying findings from this field of study to everyday life; particularly in clinical settings, and potentially any setting in which expectations regarding one’s future experiences come into play.

• Placebo
• Nocebo
• Pain
• Itch
• Learning
• Classical Conditioning
• Verbal Suggestion
• Observational Learning
• EEG
• MRI

• All authors: Blythe, J.S.
• Supervisor: Evers, A.W.M.
• Co-supervisor: Peerdeman, K.J. Veldhuijzen, D.S.
• Committee: Wouters, P.F.; Rombouts, S.A.R.B.; Dijkerman, C.; Weisshaar, E.; Wieser, M.
• Qualification: Doctor (dr.)
• Awarding Institution: Institute of Psychology, Faculty of Social and Behavioural Sciences, Leiden University
• Date: 2023-11-29
• ISBN (print): 9789464834574