Novel detectors and algorithms for electron nano-crystallography

Genderen, Eric van (2015)

Doctoral Thesis

In the past decade, advances in structure determination with electron microscopy of organic, beam sensitive, materials have been significant. The newly developed techniques, triggered by new microscope systems and new cameras, made it possible to acquire 3D structural information from these samples to a resolution which was impossible to achieve before. Knowledge is required to improve structure solution and every aspect of the process involved, from treatment of radiation sensitive materials, sample preparation, TEM imaging and diffraction systems all the way to how data must be interpreted. In this thesis I explained multiple new techniques and methods developed by us, using both new microscopes as well as a new type of detector: Timepix. I describe how these tools can help to overcome (what were) the most important problems and bottlenecks in detection of very low dose electron diffraction.

• Protein
• Crystal
• Lattice
• Phase
• Imaging
• Diffraction
• Camera
• Detector
• TEM
• Electron

• All authors: Genderen, Eric van
• Supervisor: Abrahams, J.P.; Heel, M. van
• Qualification: Doctor (dr.)
• Awarding Institution: Faculty of Science, Leiden University
• Date: 2015-12-03
• ISBN (print): 9789462599338