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Vriends, M.B.L. (2023)

Mechanism-based inhibitors and probes for neuraminidases

Doctoral Thesis
Neuraminidases are enzymes that cleave glycosidic linkages of sialic acid. These enzymes are involved in influenza infections as well as in many cellular processes in mammals and micro-organisms. Development of molecules that irreversibly inhibit these enzymes, as well as molecules that can covalently bind and also label these enzymes, is described in this thesis. These newly developed molecular tools can be used to study neuraminidsases. Better understanding of these enzymes could for example contribute to the timely invervention if new influenza strains emerge.
Neuraminidase
ABPP
Activity-Based Protein Profiling
Influenza
Oseltamivir
All authors
Vriends, M.B.L.
Supervisor
Overkleeft, H.S.; Codée, J.D.C.
Committee
Stelt, M. van der; Davies, G.J.; Rovira, C.; Kasteren, S.I. van; Artola, M.
Qualification
Doctor (dr.)
Awarding Institution
Leiden Institute of Chemistry (LIC), Faculty of Science, Leiden University
Date
2023-09-12
ISBN (print)
9789464831771