Purpose: To investigate and compare the salivary alpha amylase (sAA) activity as an indicator of the sympathetic activity and stress response in patients with central serous chorioretinopathy (CSC) and healthy controls.
Methods: Prospective, multi-center case series including 80 CSC patients and 88 healthy controls. CSC status was classified as either active or inactive, depending on the presence of subretinal fluid on optical coherence tomography (OCT). Salivary samples were collected in the morning from patients and controls of the main cohort and at midnight for the additional cohort. SAA activity was determined in all patients and controls.
Results: Morning sAA activity was significantly higher in patients with active CSC compared to inactive CSC (p=0.049) and to healthy controls (p=0.012). There was no significant difference in sAA activity between patients with inactive CSC and controls (p=1.0). Nocturnal sAA...
Show morePurpose: To investigate and compare the salivary alpha amylase (sAA) activity as an indicator of the sympathetic activity and stress response in patients with central serous chorioretinopathy (CSC) and healthy controls.
Methods: Prospective, multi-center case series including 80 CSC patients and 88 healthy controls. CSC status was classified as either active or inactive, depending on the presence of subretinal fluid on optical coherence tomography (OCT). Salivary samples were collected in the morning from patients and controls of the main cohort and at midnight for the additional cohort. SAA activity was determined in all patients and controls.
Results: Morning sAA activity was significantly higher in patients with active CSC compared to inactive CSC (p=0.049) and to healthy controls (p=0.012). There was no significant difference in sAA activity between patients with inactive CSC and controls (p=1.0). Nocturnal sAA activity did not show any significant difference between patients with active CSC and either inactive CSC or controls (p=0.139).
Conclusions: Morning sAA activity is increased in patients with active CSC, while diurnal rhythmicity is preserved. Measurement of sAA is easy to perform and might be an eligible tool to further investigate the relation between stress and CSC.
Show less
