The role of transforming growth factor beta in bicuspid aortic valve aortopathy

Grewal, N.; Dolmaci, O.; Klautz, A.; Legue, J.; Driessen, A.; Klautz, R.; Poelmann, R. (2023)

Article / Letter to editor

A bicuspid aortic valve (BAV) is the most prevalent congenital cardiac deformity, which is associated with an increased risk to develop a thoracic aortic aneurysm and/or an aortic dissection as compared to persons with a tricuspid aortic valve. Due to the high prevalence of a BAV in the general population and the associated life-long increased risk for adverse vascular events, BAV disease places a considerable burden on the public health. The aim of the present review is to discuss the role of transforming growth factor beta (TGF-ss) signaling in the development of the vascular wall and on how this complex signaling pathway may be involved in thoracic aortic aneurysm formation in tricuspid and BAV patients.

• Bicuspid aortic valve
• TGF-beta
• Thoracic aortopathy
• Molecular biology
• Embryology

• All authors: Grewal, N.; Dolmaci, O.; Klautz, A.; Legue, J.; Driessen, A.; Klautz, R.; Poelmann, R.
• Date: 2023-05-25
• Journal: Indian Journal of Thoracic and Cardiovascular Surgery
• DOI: doi:10.1007/s12055-023-01513-8