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Mertens, F.; Romeo, S.; Bovee, J.V.M.G.; Tirabosco, R.; Athanasou, N.; Alberghini, M.; ... ; Debiec-Rychter, M. (2011)

Reclassification and subtyping of so-called malignant fibrous histiocytoma of bone: comparison with cytogenetic features

Article / Letter to editor
Background: The diagnostic entity malignant fibrous histiocytoma (MFH) of bone is, like its soft tissue counterpart, likely to be a misnomer, encompassing a variety of poorly differentiated sarcomas. When reviewing a series of 57 so-called MFH of bone within the framework of the EuroBoNeT consortium according to up-to-date criteria and ancillary immunohistochemistry, a fourth of all tumors were reclassified and subtyped.Methods: In the present study, the cytogenetic data on 11 of these tumors (three myoepithelioma-like sarcomas, two leiomyosarcomas, one undifferentiated pleomorphic sarcoma with incomplete myogenic differentiation, two undifferentiated pleomorphic sarcomas, one osteosarcoma, one spindle cell sarcoma, and one unclassifiable biphasic sarcoma) are presented.Results: All tumors were high-grade lesions and showed very complex karyotypes. Neither the overall pattern (ploidy level, degree of complexity) nor specific cytogenetic features distinguished any of the subtypes....Show moreBackground: The diagnostic entity malignant fibrous histiocytoma (MFH) of bone is, like its soft tissue counterpart, likely to be a misnomer, encompassing a variety of poorly differentiated sarcomas. When reviewing a series of 57 so-called MFH of bone within the framework of the EuroBoNeT consortium according to up-to-date criteria and ancillary immunohistochemistry, a fourth of all tumors were reclassified and subtyped.Methods: In the present study, the cytogenetic data on 11 of these tumors (three myoepithelioma-like sarcomas, two leiomyosarcomas, one undifferentiated pleomorphic sarcoma with incomplete myogenic differentiation, two undifferentiated pleomorphic sarcomas, one osteosarcoma, one spindle cell sarcoma, and one unclassifiable biphasic sarcoma) are presented.Results: All tumors were high-grade lesions and showed very complex karyotypes. Neither the overall pattern (ploidy level, degree of complexity) nor specific cytogenetic features distinguished any of the subtypes. The subgroup of myoepithelioma-like sarcomas was further investigated with regard to the status of the EWSR1 and FUS loci; however, no rearrangement was found. Nor was any particular aberration that could differentiate any of the subtypes from osteosarcomas detected.Conclusions: chromosome banding analysis is unlikely to reveal potential genotype-phenotype correlations between morphologic subtypes among so-called MFH of bone.Show less
Malignant fibrous histiocytoma of bone
chromosome banding
EWSR1
FUS
All authors
Mertens, F.; Romeo, S.; Bovee, J.V.M.G.; Tirabosco, R.; Athanasou, N.; Alberghini, M.; Hogendoorn, P.C.W.; Tos, A.P.D.; Sciot, R.; Domanski, H.A.; Astrom, K.; Mandahl, N.; Debiec-Rychter, M.
Date
2011-01-01
Journal
Clinical Sarcoma Research
Volume
1
DOI
doi:10.1186/2045-3329-1-10