Advanced echocardiographic imaging in valvular and systemic diseases

Wijngaarden, S.E. van (2023)

Doctoral Thesis

This thesis describes the additional value of advanced echocardiographic techniques in patients with primary cardiac disease, resulting in mitral regurgitation, and secondary cardiac disease caused by a systemic disease. In this thesis we focussed on patients with mitral regurgitation, specifically primary MR and functional MR (FMR), and patients with Systemic Sclerosis (SSc). The general introduction provides a background of MR and cardiac involvement in SSc and how conventional 2-dimensional (2D) echocardiography is currently used. The potential role of 2D speckle tracking echocardiography and 3-dimensional (3D) echocardiography together with customized software to create 4-dimensional (4D) mitral valve models is introduced. This thesis aims to provide new insights in diagnosis, disease progression and risk stratification in patients with MR and patients with SSc with the implementation of advanced echocardiographic techniques.

• Echocardiography
• Mitral regurgitation
• Systemic sclerosis
• MitraClip
• Speckle tracking strain

• All authors: Wijngaarden, S.E. van
• Supervisor: Bax, J.J.
• Co-supervisor: Delgado, V.; Ajmone Marsan, N.
• Committee: Braun, J.; Schalij, M.J.; Huizinga, T.W.J.; Zamorano, J.L.; Vries-Bouwstra, J.K. de; Langerak, S.E.
• Qualification: Doctor (dr.)
• Awarding Institution: Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
• Date: 2023-04-13
• ISBN (print): 9789464692297
• Sponsorship: Hartstichting