Ventricular dilatation in aging and dementia

Palm, W.M. (2015)

Doctoral Thesis

The general objective of this thesis was to study the causes and consequences of ventricular dilatation in aging and dementia. For this purpose, we used ventricular shape analysis to study potential new MRI markers of cognitive decline in aging, subjective memory complaints, mild cognitive impairment and Alzheimer's Disease. In addition, we designed a volumetric measure that may objectively quantify the disproportionate ventricular dilatation that is characteristic of Normal Pressure Hydrocephalus (NPH). We investigated the value of this measure for the selection of candidates with NPH for ventricular shunting, studied its association with NPH-like symptoms in the general population and used the measure to explore a possible cardiovascular origin of cerebral ventricular dilatation.

• WMH
• AD
• MCI
• Subjective memory complaints
• Aging
• Atrophy
• CSF
• MRI

• All authors: Palm, W.M.
• Supervisor: Buchem, M.A. van
• Co-supervisor: Grond, J. van der; Launer, L.J.
• Qualification: Doctor (dr.)
• Awarding Institution: Faculty of Medicine (LUMC), Leiden University
• Date: 2015-09-29
• ISBN (print): 9789461594594