Modulating energy metabolism: pathophysiological aspects and novel interventions

Straat, M.E. (2023)

Doctoral Thesis

In this thesis, we have addressed two key objectives: 1) to gain more insight in various pathophysiological aspects of cardiometabolic diseases including in the disease prone
South Asian population, and 2) to study the physiological effects of cold exposure and identify a novel pharmacological approach to directly target BAT.

• Adiposity
• Atherosclerosis
• Cold exposure
• Dyslipidemia
• Lipid metabolism
• Obesity
• Rhythm control

• All authors: Straat, M.E.
• Supervisor: Rensen, P.C.N.
• Co-supervisor: Boon, M.R.; Martinez-Tellez, B.
• Committee: Yazdanbakhsh, M.; Pijl, H.; Roeters van Lennep, J.E.; Virtanen, K.
• Qualification: Doctor (dr.)
• Awarding Institution: Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
• Date: 2023-03-16
• ISBN (print): 9789464589313
• Sponsorship: De Nederlandse Hartstichting; Chipsoft