Splanchnic vein thrombosis-related mortality in the Veneto region (Italy), 2008-2019: retrospective analysis of epidemiological data

Turatti, G.; Fedeli, U.; Valerio, L.; Klok, F.A.; Cohen, A.T.; Hunt, B.J.; ... ; Barco, S. (2022)

Article / Letter to editor

Background: Splanchnic vein thrombosis (SVT) is an uncommon manifestation of venous thromboembolism. Epidemiological data on SVT-related mortality rate is not available to date.& nbsp;Methods: We investigated time trends in SVT-related mortality rate, 2008-2019, in Veneto, an Italian high income region of approximatively 5,000,000 inhabitants. SVT-related deaths were identified by the following ICD-10 codes: I81 (portal vein thrombosis), K75.1 (phlebitis of portal vein), K76.3 (liver infarction), K76.5 (hepatic veno-occlusive disease) or I82.0 (Budd-Chiari syndrome).& nbsp;Results: During the study period, a total of 557,932 deaths were recorded. SVT was reported in 823 cases; 776 (94%) consisted of portal vein thrombosis. The age-standardized SVT-related mortality rate varied from 1.47 (year 2008) to 1.52 (year 2019) per 100,000 person-years. An increase in the cause-specific annual mortality rate was observed in women (0.56 in 2008 to 1.04 per 100,000 person-years in 2019; average annual percent change +5.7%, 95%CI +3.1; +8.3%). In men, the cause-specific mortality rate moved from 2.53 in 2008 to 2.03 per 100,000 person-years in 2019 (average annual percent change-1.2%, 95%CI-4.0; +1.6%). After conditioning for age and sex, the odds of having a concomitant liver disease were higher for SVT-related deaths (OR 31.6; 95% CI 17.1-37.0) compared with non-SVT-related deaths. This also applies to gastrointestinal cancers (OR 1.28; 95% CI 1.07-1.55), although to a lesser extent.& nbsp;Conclusions: We report first epidemiological estimates of SVT-related mortality in a Western country. These values will serve as a reference to weight novel potential factors associated with SVT-related death and interpret them from an epidemiological perspective.

• Splanchnic vein thrombosis
• Portal vein thrombosis
• Mortality
• Epidemiology
• Venous thromboembolism
• Death

• All authors: Turatti, G.; Fedeli, U.; Valerio, L.; Klok, F.A.; Cohen, A.T.; Hunt, B.J.; Simioni, P.; Middeldorp, S.; Ageno, W.; Kucher, N.; Konstantinides, S.V.; Schievano, E.; Barco, S.
• Date: 2022-01-01
• Journal: Thrombosis Research: Vascular Obstruction, Hemorrhage and Hemostasis
• Volume: 209
• Pages: 41 - 46
• DOI: doi:10.1016/j.thromres.2021.11.005
• Link: https://www.sciencedirect.com/science/article/pii/S0049384821005132?via%...