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Mackay, T.M.; Dijksterhuis, W.P.M.; Latenstein, A.E.J.; Geest, L.G. van der; Sprangers, M.A.G.; Eijck, C.H.J. van; ... ; Oijen, M.G.H. van (2022)

The impact of cancer treatment on quality of life in patients with pancreatic and periampullary cancer: a propensity score matched analysis

Article / Letter to editor
Background: The impact of pancreatic and periampullary cancer treatment on health-related quality of life (HRQoL) is unclear.Methods: This study merged data from the Netherlands Cancer Registry with EORTC QLQ-C30 and-PAN26 questionnaires at baseline and three-months follow-up of pancreatic and periampullary cancer patients (2015-2018). Propensity score matching (1:3) of group without to group with treatment was performed. Linear mixed model regression analyses were performed to investigate the association between cancer treatment and HRQoL at follow-up.Results: After matching, 247 of 629 available patients remained (68 (27.5%) no treatment, 179 (72.5%) treatment). Treatment consisted of resection (n = 68 (27.5%)), chemotherapy only (n = 111 (44.9%)), or both (n = 40 (16.2%)). At follow-up, cancer treatment was associated with better global health status (Beta-coefficient 4.8, 95% confidence-interval 0.0-9.5) and less constipation (Beta-coefficient -7.6, 95% confidence-interval ...Show moreBackground: The impact of pancreatic and periampullary cancer treatment on health-related quality of life (HRQoL) is unclear.Methods: This study merged data from the Netherlands Cancer Registry with EORTC QLQ-C30 and-PAN26 questionnaires at baseline and three-months follow-up of pancreatic and periampullary cancer patients (2015-2018). Propensity score matching (1:3) of group without to group with treatment was performed. Linear mixed model regression analyses were performed to investigate the association between cancer treatment and HRQoL at follow-up.Results: After matching, 247 of 629 available patients remained (68 (27.5%) no treatment, 179 (72.5%) treatment). Treatment consisted of resection (n = 68 (27.5%)), chemotherapy only (n = 111 (44.9%)), or both (n = 40 (16.2%)). At follow-up, cancer treatment was associated with better global health status (Beta-coefficient 4.8, 95% confidence-interval 0.0-9.5) and less constipation (Beta-coefficient -7.6, 95% confidence-interval -13.8-1.4) compared to no cancer treatment. Median overall survival was longer for the cancer treatment group compared to the no treatment group (15.4 vs. 6.2 months, p < 0.001).Conclusion: Patients undergoing treatment for pancreatic and periampullary cancer reported slight improvement in global HRQoL and less constipation at three months-follow up compared to patients without cancer treatment, while overall survival was also improved.Show less
All authors
Mackay, T.M.; Dijksterhuis, W.P.M.; Latenstein, A.E.J.; Geest, L.G. van der; Sprangers, M.A.G.; Eijck, C.H.J. van; Homs, M.Y.V.; Luelmo, S.A.C.; Molenaar, I.Q.; Santvoort, H. van; Schreinemakers, J.M.J.; Wilmink, J.W.; Besselink, M.G.; Laarhoven, H.W. van; Oijen, M.G.H. van
Date
2022-04-13
Journal
HPB
Volume
24
Issue
4
Pages
443 - 451
DOI
doi:10.1016/j.hpb.2021.09.003