Leiden University Scholarly Publications

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Smit, J.M.; Exterkate, L.; Tienhoven, A.J. van; Haaksma, M.E.; Heldeweg, M.L.A.; Fleuren, L.; ... ; Tuinman, P.R. (2022)

Incidence, risk factors, and outcome of suspected central venous catheter-related infections in critically ill COVID-19 patients: a multicenter retrospective cohort study

Article / Letter to editor
Background: Aims of this study were to investigate the prevalence and incidence of catheter-related infection, identify risk factors, and determine the relation of catheter-related infection with mortality in critically ill COVID-19 patients. Methods: This was a retrospective cohort study of central venous catheters (CVCs) in critically ill COVID-19 patients. Eligible CVC insertions required an indwelling time of at least 48 hours and were identified using a full-admission electronic health record database. Risk factors were identified using logistic regression. Differences in survival rates at day 28 of follow-up were assessed using a log-rank test and proportional hazard model. Results: In 538 patients, a total of 914 CVCs were included. Prevalence and incidence of suspected catheter-related infection were 7.9% and 9.4 infections per 1,000 catheter indwelling days, respectively. Prone ventilation for more than 5 days was associated with increased risk of suspected catheter...Show moreBackground: Aims of this study were to investigate the prevalence and incidence of catheter-related infection, identify risk factors, and determine the relation of catheter-related infection with mortality in critically ill COVID-19 patients. Methods: This was a retrospective cohort study of central venous catheters (CVCs) in critically ill COVID-19 patients. Eligible CVC insertions required an indwelling time of at least 48 hours and were identified using a full-admission electronic health record database. Risk factors were identified using logistic regression. Differences in survival rates at day 28 of follow-up were assessed using a log-rank test and proportional hazard model. Results: In 538 patients, a total of 914 CVCs were included. Prevalence and incidence of suspected catheter-related infection were 7.9% and 9.4 infections per 1,000 catheter indwelling days, respectively. Prone ventilation for more than 5 days was associated with increased risk of suspected catheter-related infection; odds ratio, 5.05 (95% confidence interval 2.12-11.0). Risk of death was significantly higher in patients with suspected catheter-related infection (hazard ratio, 1.78; 95% confidence interval, 1.25-2.53). Conclusions: This study shows that in critically ill patients with COVID-19, prevalence and incidence of suspected catheter-related infection are high, prone ventilation is a risk factor, and mortality is higher in case of catheter-related infection.Show less
Central venous catheters
catheter-related infections
COVID-19
intensive care
All authors
Smit, J.M.; Exterkate, L.; Tienhoven, A.J. van; Haaksma, M.E.; Heldeweg, M.L.A.; Fleuren, L.; Thoral, P.; Dam, T.A.; Heunks, L.M.A.; Gommers, D.; Cremer, O.L.; Bosman, R.J.; Rigter, S.; Wils, E.J.; Frenzel, T.; Vlaar, A.P.; Dongelmans, D.A.; Jong, R. de; Peters, M.; Kamps, M.J.A.; Ramnarain, D.; Nowitzky, R.; Nooteboom, F.G.C.A.; Ruijter, W. de; Urlings-Strop, L.C.; Smit, E.G.M.; Mehagnoul-Schipper, D.J.; Dormans, T.; Jager, C.P.C. de; Hendriks, S.H.A.; Achterberg, S.; Oostdijk, E.; Reidinga, A.C.; Festen-Spanjer, B.; Brunnekreef, G.B.; Cornet, A.D.; Tempel, W. van den; Boelens, A.D.; Koetsier, P.; Lens, J.; Faber, H.J.; Karakus, A.; Entjes, R.; Jong, P. de; Rettig, T.C.D.; Arbous, S.; Vonk, B.; Machado, T.; Girbes, A.R.J.; Sieswerda, E.; Elbers, P.W.G.; Tuinman, P.R.
Date
2022-11-01
Journal
Shock: Injury, Inflammation and Sepsis
Volume
58
Issue
5
Pages
358 - 365
DOI
doi:10.1097/SHK.0000000000001994