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Association of apolipoproteins C-I, C-II, C-III and E with coagulation markers and venous thromboembolism risk
thrombotic diseases. We investigated whether these apolipoproteins have prothrombotic
properties and are associated with risk of venous thromboembolism (VTE).
Patients and methods: A total of 127 VTE patients and 299 controls were randomly
selected from the Multiple Environmental and Genetic Assessment of Risk Factors for
Venous Thrombosis study (1999–2004), in the Netherlands. The apolipoproteins were quan-
tified using mass spectrometry (LC/MS/MS), and their levels were analyzed as continuous
variable (per SD increase).
Results: In controls, increases in levels of apolipoproteins were associated with increases in
levels of vitamin K-dependent factors, factor XI, antithrombin and clot lysis time.
Additionally, increasing apolipoproteins C-III and E levels were associated with higher
factor VIII and von Willebrand factor levels. Levels of C-reactive protein...Show morePurpose: Apolipoproteins C-I, C-II, C-III and E have been associated with risk of arterial
thrombotic diseases. We investigated whether these apolipoproteins have prothrombotic
properties and are associated with risk of venous thromboembolism (VTE).
Patients and methods: A total of 127 VTE patients and 299 controls were randomly
selected from the Multiple Environmental and Genetic Assessment of Risk Factors for
Venous Thrombosis study (1999–2004), in the Netherlands. The apolipoproteins were quan-
tified using mass spectrometry (LC/MS/MS), and their levels were analyzed as continuous
variable (per SD increase).
Results: In controls, increases in levels of apolipoproteins were associated with increases in
levels of vitamin K-dependent factors, factor XI, antithrombin and clot lysis time.
Additionally, increasing apolipoproteins C-III and E levels were associated with higher
factor VIII and von Willebrand factor levels. Levels of C-reactive protein were not associated
with any apolipoprotein. The age- and sex-adjusted odds ratios of apolipoproteins E, C-III,
CII and CI to the risk of venous thrombosis were 1.21 (95% CI, 0.98–1.49), 1.19 (95% CI,
0.99–1.44), 1.24 (95% CI, 0.95–1.61) and 1.06 (95% CI, 0.87–1.30) per SD increase,
respectively. These odds ratios did not attenuate after adjustments for statin use, estrogen
use, BMI, alcohol use, and self-reported diabetes.
Conclusions: Levels of apolipoproteins C-I, C-II, C-III and E are associated with those of
several coagulation factors. However, whether these apolipoproteins are also associated with
an increased risk of VTE remains to be established.
Keywords: thrombosis, proteomics, lipids, cholesterol, coagulation, risk factors
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- All authors
- Orsi, F.A.; Lijfering, W.M.; Laarse, A. van der; Ruhaak, L.R.; Rosendaal, F.R.; Cannegieter, S.C.; Cobbaert, C.
- Date
- 2019
- Journal
- Clinical Epidemiology
- Volume
- 11
- Pages
- 625 - 633