Impact of the COVID-19-pandemic on patients with gynecological malignancies undergoing surgery: a Dutch population-based study using data from the 'Dutch Gynecological Oncology Audit'

Algera, M.D.; Driel, W.J. van; Slangen, B.F.M.; Kruitwagen, R.F.P.M.; Wouters, M.W.J.M.; Baalbergen, A.; ... ; Ham, M.A.P.C. van (2022)

Article / Letter to editor

Objective. The COVID-19-pandemic caused drastic healthcare changes worldwide. To date, the impact of these changes on gynecological cancer healthcare is relatively unknown. This study aimed to assess the impact of the COVID-19-pandemic on surgical gynecological-oncology healthcare. Methods. This population-based cohort study included all surgical procedures with curative intent for gynecological malignancies, registered in the Dutch Gynecological Oncology Audit, in 2018-2020. Four periods were identified based on COVID-19 hospital admission rates: 'Pre-COVID-19', 'Firstwave', 'Interimperiod', and'Second wave'. Surgical volume, perioperative care processes, and postoperative outcomes from 2020 were compared with 2018-2019. Results. A total of 11,488 surgical procedureswere analyzed. For cervical cancer, surgical volume decreased by 17.2% in 2020 compared to 2018-2019 (mean 2018-2019: n= 542.5, 2020: n= 449). At nadir (interimperiod), only 51% of the expected cervical cancer procedures were performed. For ovarian, vulvar, and endometrial cancer, volumes remained stable. Patients with advanced-stage ovarian cancer more frequently received neoadjuvant chemotherapy in 2020 compared to 2018-2019 (67.7% (n = 432) vs. 61.8% (n = 783), p = 0.011). Median time to first treatmentwas significantly shorter in all four malignancies in 2020. For vulvar and endometrial cancer, the length of hospital staywas significantly shorter in 2020. No significant differences in complicated course and 30-day-mortality were observed. Conclusions. The COVID-19-pandemic impacted surgical gynecological-oncology healthcare: in 2020, surgical volume for cervical cancer dropped considerably, waiting time was significantly shorter for all malignancies, while neoadjuvant chemotherapy administration for advanced-stage ovarian cancer increased. The safety of perioperative healthcare was not negatively impacted by the pandemic, as complications and 30-day-mortality remained stable. (C) 2022 The Authors. Published by Elsevier Inc.

• Surgical volume
• Perioperative care processes
• Postoperative outcomes
• Gynecological oncology
• Ovarian cancer
• Vulvar cancer
• Endometrial cancer
• Cervical cancer
• Impact COVID-19
• Pandemic

• All authors: Algera, M.D.; Driel, W.J. van; Slangen, B.F.M.; Kruitwagen, R.F.P.M.; Wouters, M.W.J.M.; Baalbergen, A.; Cate, A.D. ten; Aalders, A.L.; Kolk, A. van der; Kruse, A.J.; Haaften-deJong, A.M.L.D. van; Swaluw, A.M.G. van de; Visschers, B.A.J.T.; Buis, C.C.N.; Gerestein, C.G.; Smeets, C.M.W.H.; Boll, D.; Laar, R. van de; Ngo, D.H.; Davelaar, E.; Ooms, E.A.; Dorst, E.B.L. van; Schmeink, C.E.; Es, E.J.M. van; Roes, E.M.; Cate, F.A. ten; Rijcken, F.E.M.; Rosier-van Dunne, F.M.R.; Fons, G.; Jansen, G.H.; Verhoeve, H.R.; Nagel, H.T.C.; Keizer, H.H.; Smedts, H.P.M.; Ebisch, I.M.W.; Lande, J. van de; Louwers, J.A.; Briet, J.; Waard, J. de; Diepstraten, J.; Vollebergh, J.H.A.; Avoort, I.A.M. van der; Dijk, J.E.W. van; Lange, J.G.; Mens, J.W.M.; Gaarenstroom, K.N.; Overmars, K.; Vries, L.C. de; Hofman, L.N.; Bartelink, L.R.; Huisman, M.A.; Verbruggen, M.B.; Vos, M.C.; Huisman, M.; Kleppe, M.; Hende, M. van den; Aa, M. van der; Wust, M.D.; Baas, M.I.; Engelen, M.J.A.; Scheers, E.C.A.H.; Moonen-Delarue, M.W.G.; Tjiong, M.Y.; Leffers, N.; Reesink, N.; Timmers, P.J.; Kolk, P.; Vencken, P.M.L.H.; Yigit, R.; Smit, R.A.; Westenberg, S.M.; Coppus, S.F.P.J.; Stam, T.C.; Schukken, T.K.; Baal, W.M. van; Minderhoud-Bassie, W.; Plas-Koning, Y.W.C.M. van der; Ham, M.A.P.C. van
• Date: 2022-05-01
• Journal: Gynecologic Oncology
• Volume: 165
• Issue: 2
• Pages: 330 - 338
• DOI: doi:10.1016/j.ygyno.2022.02.013