Leiden University Scholarly Publications

Persistent URL of this record https://hdl.handle.net/1887/3502242

In Collections

This item can be found in the following collections:

Schellekens, M.M.I.; Boot, E.M.; Verhoeven, J.I.; Ekker, M.S.; Alebeek, M.E. van; Brouwers, P.J.A.M.; ... ; Tuladhar, A.M. (2022)

Subacute cognitive impairment after first-ever transient ischemic attack or ischemic stroke in young adults: the ODYSSEY study

Article / Letter to editor
Introduction: We aimed to investigate the prevalence of cognitive impairment in the subacute phase after transient ischemic attack (TIA) and ischemic stroke (IS), factors associated with a vascular cognitive disorder, and the prevalence of subjective cognitive complaints and their relation with objective cognitive performance. Patients and methods: In this multicenter prospective cohort study, we recruited patients with first-ever TIA and IS, aged 18-49 years, between 2013 and 2021 for cognitive assessment up to 6 months after index event. We calculated composite Z-scores for seven cognitive domains. We defined cognitive impairment as a composite Z-score < -1.5. We defined major vascular cognitive disorder as a Z-score < -2.0 in one or more cognitive domains. Results: Fifty three TIA and 545 IS patients completed cognitive assessment with mean time to assessment of 89.7 (SD 40.7) days. The median NIHSS at admission was 3 (interquartile range, 1-5). Cognitive impairment was common in...Show moreIntroduction: We aimed to investigate the prevalence of cognitive impairment in the subacute phase after transient ischemic attack (TIA) and ischemic stroke (IS), factors associated with a vascular cognitive disorder, and the prevalence of subjective cognitive complaints and their relation with objective cognitive performance. Patients and methods: In this multicenter prospective cohort study, we recruited patients with first-ever TIA and IS, aged 18-49 years, between 2013 and 2021 for cognitive assessment up to 6 months after index event. We calculated composite Z-scores for seven cognitive domains. We defined cognitive impairment as a composite Z-score < -1.5. We defined major vascular cognitive disorder as a Z-score < -2.0 in one or more cognitive domains. Results: Fifty three TIA and 545 IS patients completed cognitive assessment with mean time to assessment of 89.7 (SD 40.7) days. The median NIHSS at admission was 3 (interquartile range, 1-5). Cognitive impairment was common in five domains (up to 37%), with similar proportion in TIA and IS patients. Patients with major vascular cognitive disorder had a lower education level, higher NIHSS scores and more frequent lesions in the left frontotemporal lobe than without vascular cognitive disorder (p < 0.05 FDR-corrected). Subjective memory and executive cognitive complaints were present in about two-thirds of the patients, but were weakly associated with objective cognitive performance (beta: -0.32 and -0.21, respectively). Discussion and conclusion: In the subacute phase after TIA or stroke in young adults, cognitive impairment and subjective cognitive complaints are prevalent, but they are weakly associated with each other.Show less
Cognitive impairment
stroke in young adults
neuropsychological tests
subjective cognitive complaints
All authors
Schellekens, M.M.I.; Boot, E.M.; Verhoeven, J.I.; Ekker, M.S.; Alebeek, M.E. van; Brouwers, P.J.A.M.; Arntz, R.M.; Dijk, G.W. van; Gons, R.A.R.; Uden, I.W.M. van; Heijer, T. den; Kort, P.L.M. de; Laat, K.F. de; Norden, A. van; Vermeer, S.E.; Zagten, M.S.G. van; Oostenbrugge, R.J. van; Wermer, M.J.; Nederkoorn, P.J.; Rooij, F.G. van; Wijngaard, I.R. van den; Leeuw, F.E. de; Kessels, R.P.C.; Tuladhar, A.M.
Date
2022-10-31
Journal
European Stroke Journal
Volume
8
Issue
1
Pages
283 - 293
DOI
doi:10.1177/23969873221132032
Link
https://journals.sagepub.com/doi/10.1177/23969873221132032