Systemic sclerosis: are anti-nuclear antibodies our guiding stars?

Boonstra, M. (2022)

Doctoral Thesis

In this thesis the role of anti-nuclear antibodies to function as biomarkers in systemic sclerosis has been evaluated. Respectively, the heterogeneity of the disease, the need for biomarkers and the role of auto-antibodies to function as such, with specific attention for anti-topoisomerase I, have been outlined in this thesis.

• Auto-antibodies
• Biomarkers
• Anti-topoisomerase
• Scl70

• All authors: Boonstra, M.
• Supervisor: Huizinga, T.W.J.
• Co-supervisor: Vries-Bouwstra, J.K. de
• Committee: Toes, R.E.M.; Helm-van Mil, A.H.M. van der; Voskuyl, A.E.; Ninaber, M.K.; Bultink, I.E.M.
• Qualification: Doctor (dr.)
• Awarding Institution: Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
• Date: 2022-11-08
• Sponsorship: Boehringer Ingelheim; Chipsoft; Stichting NVLE fonds