Bleeding in hemato-oncology patients: beyond the platelet paradigm

Cornelissen, L.L. (2022)

Doctoral Thesis

Bleeding events are frequently encountered in hemato-oncology patients. To prevent this, in periods of thrombocytopenia patients receive prophylactic platelet transfusions, based on the platelet counts. However, beside platelet counts many other patients factors likely contribute to the bleeding risk.
In this thesis we focus on describing current clinical practice to prevent bleedings in a subpopulation of patients with persistent deep thrombocytopenia, risk factors for bleeding, and prediction of bleeding. We also describe a ongoing study which aims to identify and quantify risk factors in future.
With this knowledge, in the ultimate goal is to predict bleeding more accurate based on patient characteristics and/or biomarkers. This could be a first step towards more personalized bleeding prevention strategies.

• Bleeding
• Intracranial hemorrhage
• Hemato-oncology
• Leukemia
• Platelet counts
• Platelet transfusions
• Prevention

• All authors: Cornelissen, L.L.
• Supervisor: Zwaginga, J.J.; Bom, J.G. van der
• Co-supervisor: Caram Deelder, C.
• Committee: Cannegieter, S.C.; Stanworth, S.J.; Veelken, J.H.; Voorberg, J.J.
• Qualification: Doctor (dr.)
• Awarding Institution: Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
• Date: 2022-06-22
• ISBN (print): 9789464238488