Endoglin and the immune system: immunomodulation and therapeutic opportunities for cancer

Schoonderwoerd, M.J.A. (2022)

Doctoral Thesis

The TME has increasingly been recognized as an important player in tumor progression and metastasis and a possible target for therapy. The TME consists of multiple cell types secreting growth factors and cytokines that exert either pro- or anti-tumor effects. This thesis mainly focuses on studies of the TME, especially the effects of Endoglin, on several cell types within the TME, including endothelial cells, fibroblasts, and immune cells.
The TME has increasingly been recognized as an important player in tumor progression and metastasis and a possible target for therapy. The TME consists of multiple cell types secreting growth factors and cytokines that exert either pro- or anti-tumor effects. This thesis mainly focusses on studies of the TME, especially the effects of Endoglin, on several cell types within the TME, including endothelial cells, fibroblasts, and immune cells. This thesis aims to unravel the role of Endoglin as a possible target on various cell types within the TME of solid tumors. Endoglin is known for its role during angiogenesis, however, an increasing number of studies have shown the importance of Endoglin expression on several other cell types (e.g., immune cells, CAFs, tumor cells).

• Endoglin
• Immunotherapy
• TRC105
• Fibroblasts
• CRC

• All authors: Schoonderwoerd, M.J.A.
• Supervisor: Hardwick, J.C.H.
• Co-supervisor: Hawinkels, L.J.A.C.; Fransen, M.F.
• Committee: Goumans, M.T.H.; Ossendorp, F.; Snaar, B.E.; Prakash, J.; Bernabeu, C.
• Qualification: Doctor (dr.)
• Awarding Institution: Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
• Date: 2022-05-12
• ISBN (print): 9789464237740