Multi-modality imaging in ischemic heart disease, arrhythmia and cardiac-mechanics

El Mahdiui, M. (2022)

Doctoral Thesis

In this thesis, the role of multi-modality imaging in ischemic heart disease, arrhythmias and cardiac mechanics is investigated. Computed tomography (CT) is utilized to evaluate the role of sex on progression of coronary artery disease (CAD) and the relationship between anatomical and functional markers of CAD. Reference values for a novel technique, non-invasive myocardial work, are presented for different cardiac pathologies and its relation with the extent of infarct transmurality following ST-segment elevation myocardial infarction is evaluated. The prognostic value of left ventricular (LV) global longitudinal strain (GLS) on 2-dimensional speckle tracking echocardiography and heart-to-mediastinum ratio on 123I-MIBG scintigraphy on appropriate Implantable Cardioverter Defibrillator (ICD) therapy is evaluated. Furthermore, the predictive value of posterior left atrial adipose tissue attenuation on CT for atrial fibrillation recurrence following ablation is investigated.

• Ischemic heart disease
• Arrhythmias
• Cardiac imaging
• Multi-modality imaging
• Myocardial work

• All authors: El Mahdiui, M.
• Supervisor: Bax, J.J.; Jukema, J.W.
• Co-supervisor: Delago, V.
• Committee: Reiber, J.H.C.; Gimelli, A.; Knuuti, J.; Bootsma, M.; Ajmone Marsan, N.
• Qualification: Doctor (dr.)
• Awarding Institution: Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
• Date: 2022-05-10
• ISBN (print): 9789464217179
• Sponsorship: Boehringer Ingelheim bv, Canon Medical Systems Nederland, Medis Medical Imaging Systems bv and Chipsoft bv