Advanced echocardiography in characterization and management of patients with secondary mitral regurgitation

Namazi, F. (2022)

Doctoral Thesis

Severe secondary MR is known to be associated with a worse prognosis, whilst the effect of reducing MR on prognosis has still been unclear. The question remains what influences the prognosis of these patients: is it the LV or the valve (i.e. the MR)? Characterization and risk-stratification of patients with secondary MR therefore remains challenging. Until recently the decision to intervene for secondary MR was based also on the LVEF. However, LVEF is subject to many limitations. Advanced echocardiography, such as speckle tracking echocardiography, from which LVGLS could be derived has shown to be of much more diagnostic and prognostic value in various valvular heart disease and is currently being implemented more in valvular heart disease guidelines. This supports the fact that LVGLS can detect LV dysfunction in an earlier stage and therefore guide physicians to refer patients for intervention before it is too late. Also the mitral valve geometry has an important role in the technical feasibility of intervention, but also could elaborate on which specific transcatheter intervention is more appropriate according to their targets (i.e. leaflets, annulus or sub apparatus). Additionally, multimodality imaging remains key in characterization and quantification of secondary MR and may help further risk-stratification.

• Secondary mitral regurgitation
• Prognosis
• Echocardiography
• Multimodality imaging
• Speckle tracking echocardiography
• Heart failure

• All authors: Namazi, F.
• Supervisor: Bax, J.J.
• Co-supervisor: Delgado, V.; Ajmone Marsan, N.
• Committee: Braun, J.; Klautz, R.J.M.; Crespo-Leiro, M.; Bootsma, M.; Timmer, J.R.
• Qualification: Doctor (dr.)
• Awarding Institution: Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
• Date: 2022-05-10
• ISBN (print): 9789463328173