Full-thickness scar resection after R1/Rx excised T1 colorectal cancers as an alternative to completion surgery

Gijsbers, K.M.; Lacle, M.M.; Elias, S.G.; Backes, Y.; Bosman, J.H.; Berkel, A.M. van; Boersma, F.; Boonstra, J.J.; Bos, P.R.; Dekker, P.A.T.; Didden, P.D.; Geesing, J.M.J.; Groen, J.N.; Haasnoot, K.J.C.; Kessels, K.; Lent, A.U.G. van; Schee, L. van der; Schrauwen, R.W.M.; Schreuder, R.M.; Schwartz, M.P.; Seerden, T.J.; Spanier, M.B.W.M.; Droste, J.S.T.S.; Tuynman, J.B.; Cappel, W.H.D.T.N.; Westreenen, E.H.L. van; Wolfhagen, F.H.J.; Vleggaar, F.P.; Borg, F. ter; Moons, L.M.G.; Dutch T1 CRC Working Grp

doi:doi:10.14309/ajg.0000000000001621

INTRODUCTION: Local full-thickness resections of the scar (FTRS) after local excision of a T1 colorectal cancer (CRC) with uncertain resection margins is proposed as an alternative strategy to completion surgery (CS), provided that no local intramural residual cancer (LIRC) is found. However, a comparison on long-term oncological outcome between both strategies is missing.METHODS: A large cohort of patients with consecutive T1 CRC between 2000 and 2017 was used. Patients were selected if they underwent a macroscopically complete local excision of a T1 CRC but positive or unassessable (R1/Rx) resection margins at histology and without lymphovascular invasion or poor differentiation. Patients treated with CS or FTRS were compared on the presence of CRC recurrence, a 5-year overall survival, disease-free survival, and metastasis-free survival.RESULTS: Of 3,697 patients with a T1 CRC, 434 met the inclusion criteria (mean age 66 years, 61% men). Three hundred thirty-four patients...Show moreINTRODUCTION: Local full-thickness resections of the scar (FTRS) after local excision of a T1 colorectal cancer (CRC) with uncertain resection margins is proposed as an alternative strategy to completion surgery (CS), provided that no local intramural residual cancer (LIRC) is found. However, a comparison on long-term oncological outcome between both strategies is missing.METHODS: A large cohort of patients with consecutive T1 CRC between 2000 and 2017 was used. Patients were selected if they underwent a macroscopically complete local excision of a T1 CRC but positive or unassessable (R1/Rx) resection margins at histology and without lymphovascular invasion or poor differentiation. Patients treated with CS or FTRS were compared on the presence of CRC recurrence, a 5-year overall survival, disease-free survival, and metastasis-free survival.RESULTS: Of 3,697 patients with a T1 CRC, 434 met the inclusion criteria (mean age 66 years, 61% men). Three hundred thirty-four patients underwent CS, and 100 patients underwent FTRS. The median follow-up period was 64 months. CRC recurrence was seen in 7 patients who underwent CS (2.2%, 95% CI 0.9%-4.6%) and in 8 patients who underwent FTRS (9.0%, 95% CI 3.9%-17.7%). Disease-free survival was lower in FTRS strategy (96.8% vs 89.9%, P=0.019), but 5 of the 8 FTRS recurrences could be treated with salvage surgery. The metastasis-free survival (CS 96.8% vs FTRS 92.1%, P=0.10) and overall survival (CS 95.6% vs FTRS 94.4%, P=0.55) did not differ significantly between both strategies.DISCUSSION: FTRS after local excision of a T1 CRC with R1/Rx resection margins as a sole risk factor, followed by surveillance and salvage surgery in case of CRC recurrence, could be a valid alternative strategy to CS.Show less

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Full-thickness scar resection after R1/Rx excised T1 colorectal cancers as an alternative to completion surgery