Migraine biochemistry and visual snow

Dongen, R.M. van (2022)

Doctoral Thesis

The research in this thesis is divided into two parts. Part I consists of biochemical studies in migraine, a paroxysmal brain disorder where visual disturbances may form a part of the migraine attack. The main objective was quantification of amine neurotransmitters and other amine molecules in cerebrospinal fluid and plasma of migraine patients, and compare these concentrations with those from healthy controls. Part II describes the clinical relation between migraine and visual snow, a brain disorder with continuous visual disturbances and that is possibly associated with migraine. Since not much is known about this relationship this thesis presents observational studies on the incidence of comorbid migraine in visual snow.

• Migraine
• Headache
• Metabolomics
• Amines
• Glutamate
• Arginine
• Neurotransmitters
• Visual snow
• Hyperexcitability
• Hallucinogen persisting perception disorder

• All authors: Dongen, R.M. van
• Supervisor: Ferrari, M.D.; Maagdenberg, A.M.J.M. van den; Terwindt, G.M.
• Committee: Wee, N.J.A. van der; Hankemeier, T.; Maassen van den Brink, A.; Portielje, J.E.A.
• Qualification: Doctor (dr.)
• Awarding Institution: Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
• Date: 2022-03-31