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New research strategies in retroperitoneal sarcoma: the case of TARPSWG, STRASS and RESAR - making progress through collaboration.
Retroperitoneal sarcoma (RPS) is a rare disease, and until recently, its natural history and outcome were
poorly understood. Recently, collaborations between individual centers have led to an unprecedented
collection of retrospective and prospective data and successful recruitment to the first randomized trial as
described here.
Recent findings
A debate about the beneficial role of extended surgery in RPS triggered an initial collaboration between
Europe and North America, the TransAtlantic RetroPeritoneal Sarcoma Working Group (TARPSWG). This
collaboration has been instrumental in harmonizing the surgical approach among expert centers,
characterizing the pattern of postresection failure of the different histological subtypes, identifying new
ways to stage RPS and testing the role of preoperative radiotherapy in a randomized fashion (STRASS-1
study). The collaboration has now expanded to include centers from Asia, Australia and...Show morePurpose of review
Retroperitoneal sarcoma (RPS) is a rare disease, and until recently, its natural history and outcome were
poorly understood. Recently, collaborations between individual centers have led to an unprecedented
collection of retrospective and prospective data and successful recruitment to the first randomized trial as
described here.
Recent findings
A debate about the beneficial role of extended surgery in RPS triggered an initial collaboration between
Europe and North America, the TransAtlantic RetroPeritoneal Sarcoma Working Group (TARPSWG). This
collaboration has been instrumental in harmonizing the surgical approach among expert centers,
characterizing the pattern of postresection failure of the different histological subtypes, identifying new
ways to stage RPS and testing the role of preoperative radiotherapy in a randomized fashion (STRASS-1
study). The collaboration has now expanded to include centers from Asia, Australia and South America. A
prospective registry has been started and a new randomized trial, STRASS-2, is in preparation to analyze
the role of neoadjuvant chemotherapy for high-grade liposarcoma and leiomyosarcoma of the
retroperitoneum.
Summary
Collaboration is critical to study a rare disease like RPS. Both retrospective and prospective data are useful to
improve knowledge, generate hypotheses and build evidence to test, whenever possible, in clinical trials.
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- All authors
- Houdt, W.J. van; Raut, C.P.; Bonvalot, S.; Swallow, C.J.; Haas, R.; Gronchi, A.
- Date
- 2019
- Journal
- Current Opinion in Oncology
- Volume
- 31
- Issue
- 4
- Pages
- 310 - 316