The dynamics of B cell aging in health and disease

Mol, J. de; Kuiper, J.; Tsiantoulas, D.; Foks, A.C. (2021)

Article / Letter to editor

Aging is considered to be an important risk factor for several inflammatory diseases. B cells play a major role in chronic inflammatory diseases by antibody secretion, antigen presentation and T cell regulation. Different B cell subsets have been implicated in infections and multiple autoimmune diseases. Since aging decreases B cell numbers, affects B cell subsets and impairs antibody responses, the aged B cell is expected to have major impacts on the development and progression of these diseases. In this review, we summarize the role of B cells in health and disease settings, such as atherosclerotic disease. Furthermore, we provide an overview of age-related changes in B cell development and function with respect to their impact in chronic inflammatory diseases.

• B cells
• Aging
• Inflammaging
• Immunosenescence
• Autoimmune Diseases
• Atherosclerosis

• All authors: Mol, J. de; Kuiper, J.; Tsiantoulas, D.; Foks, A.C.
• Date: 2021-10-05
• Journal: Frontiers in Immunology
• Volume: 12
• DOI: doi:10.3389/fimmu.2021.733566