PAKC: a novel panel of HLA class I antigen presentation machinery knockout cells from the same genetic origin

Waard, A.A. de; Verkerk, T.; Jongsma, M.L.M.; Hoefakker, K.; Sethumadhavan, S.; Gerke, C.; ... ; Spaapen, R.M. (2021)

Other

A single model system for integrative studies on multiple facets of antigen presentation is lacking. PAKC is a novel panel of ten cell lines knocked out for individual components of the HLA class I antigen presentation pathway. PAKC will accelerate HLA-I research in the fields of oncology, infectiology, and autoimmunity.

• APM
• antigen presentation
• HLA class I
• CRISPR
• Cas9
• MHC

• All authors: Waard, A.A. de; Verkerk, T.; Jongsma, M.L.M.; Hoefakker, K.; Sethumadhavan, S.; Gerke, C.; Bliss, S.; Kong, X.R.; Janssen, G.M.C.; Ru, A.H. de; Claas, F.H.J.; Mulder, A.; Tampe, R.; Veelen, P.A. van; Halenius, A.; Spaapen, R.M.
• Date: 2021-02-01
• Title of host publication: European Journal of Immunology
• Volume: 51
• Issue: 3
• Pages: 734 - 737
• DOI: doi:10.1002/eji.202048599
• Link: https://onlinelibrary.wiley.com/doi/10.1002/eji.202048599