Leiden University Scholarly Publications

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Dijk, H.J.M. van; Marel, G.A. van der; Codée, J.D.C. (2021)

Developments in the synthesis of mycobacterial phenolic glycolipids

Article / Letter to editor
The highly lipophilic outer barrier of mycobacteria, such as M. tuberculosis and M. leprae, is key to their virulence and intrinsic antibiotic resistance. Various components of this mycomembrane interact with the host immune system but many of these interactions remain ill-understood. This review covers several chemical syntheses of one of these components, mycobacterial phenolic glycolipids (PGLs), and outlines the interaction of these PGLs with the human immune system, as established using these well-defined pure compounds.
All authors
Dijk, H.J.M. van; Marel, G.A. van der; Codée, J.D.C.
Date
2021-09-28
Journal
Chemical Record
Volume
21
Pages
1 - 19
Advanced Publication
Yes
DOI
doi:10.1002/tcr.202100200
Link
https://onlinelibrary.wiley.com/doi/10.1002/tcr.202100200