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Trzcionkowska, K.; Groenendaal, F.; Andriessen, P.; Dijk, P.H.; Dungen, F.A.M. van den; Hillegersberg, J.L. van; ... ; Termote, J.U.M. (2021)

Risk factors for retinopathy of prematurity in the Netherlands: a comparison of two cohorts

Article / Letter to editor
Introduction: Retinopathy of prematurity (ROP) remains an important cause for preventable blindness. Aside from gestational age (GA) and birth weight, risk factor assessment can be important for determination of infants at risk of (severe) ROP. Methods: Prospective, multivariable risk-analysis study (NEDROP-2) was conducted, including all infants born in 2017 in the Netherlands considered eligible for ROP screening by pediatricians. Ophthalmologists provided data of screened infants, which were combined with risk factors from the national perinatal database (Perined). Clinical data and potential risk factors were compared to the first national ROP inventory (NEDROP-1, 2009). During the second period, more strict risk factor-based screening inclusion criteria were applied. Results: Of 1,287 eligible infants, 933 (72.5%) were screened for ROP and matched with the Perined data. Any ROP was found in 264 infants (28.3% of screened population, 2009: 21.9%) and severe ROP (sROP) (stage >=...Show moreIntroduction: Retinopathy of prematurity (ROP) remains an important cause for preventable blindness. Aside from gestational age (GA) and birth weight, risk factor assessment can be important for determination of infants at risk of (severe) ROP. Methods: Prospective, multivariable risk-analysis study (NEDROP-2) was conducted, including all infants born in 2017 in the Netherlands considered eligible for ROP screening by pediatricians. Ophthalmologists provided data of screened infants, which were combined with risk factors from the national perinatal database (Perined). Clinical data and potential risk factors were compared to the first national ROP inventory (NEDROP-1, 2009). During the second period, more strict risk factor-based screening inclusion criteria were applied. Results: Of 1,287 eligible infants, 933 (72.5%) were screened for ROP and matched with the Perined data. Any ROP was found in 264 infants (28.3% of screened population, 2009: 21.9%) and severe ROP (sROP) (stage >= 3) in 41 infants (4.4%, 2009: 2.1%). The risk for any ROP is decreased with a higher GA (odds ratio [OR] 0.59 and 95% confidence interval [CI] 0.54-0.66) and increased for small for GA (SGA) (1.73, 1.11-2.62), mechanical ventilation >7 days (2.13, 1.35-3.37) and postnatal corticosteroids (2.57, 1.44-4.66). For sROP, significant factors were GA (OR 0.37 and CI 0.27-0.50), SGA (OR 5.65 and CI 2.17-14.92), postnatal corticosteroids (OR 3.81 and CI 1.72-8.40), and perforated necrotizing enterocolitis (OR 7.55 and CI 2.29-24.48). Conclusion: In the Netherlands, sROP was diagnosed more frequently since 2009. No new risk factors for ROP were determined in the present study, apart from those already included in the current screening guideline.Show less
Retinopathy of prematurity
Prematurity and screening
All authors
Trzcionkowska, K.; Groenendaal, F.; Andriessen, P.; Dijk, P.H.; Dungen, F.A.M. van den; Hillegersberg, J.L. van; Koole, S.; Kornelisse, R.F.; Westering-Kroon, E. van; Lindern, J.S. von; Meijssen, C.B.; Schuerman, F.A.B.A.; Steiner, K.; Tuyl, M.W.G. van; Witlox, R.S.G.M.; Schalij-Delfos, N.E.; Termote, J.U.M.
Date
2021-07-22
Journal
Neonatology
Volume
118
Issue
4
Pages
462 - 469
DOI
doi:10.1159/000517247
Link
https://www.karger.com/Article/Pdf/517247