Population pharmacokinetic modelling of intravenous paracetamol in fit older people displays extensive unexplained variability.

Mian, P.; Esdonk, M.J. van; Olkkola, K.T.; Winter, B.C.M. de; Liukas, A.; Spriet, I.; ... ; Allegaert, K. (2018)

Article / Letter to editor

as target for effective analgesia.A population PK-analysis, using NONMEM 7.2, was performed based on 601 concentrations of paracetamol from 30 fit older people (median age 77.3 years, range [61.8-88.5], body weight 79 kg [60-107]). All had received an IV paracetamol dose of 1000 mg (over 15 min) after elective knee surgery. , respectively, in 90% of the population and above 15.5 and 11.7, respectively, in 10% at these dosing regimens.The target concentration was achieved in the average patient with 1000 mg every 6 h, while every 8 h resulted in underdosing for the majority of the population. Furthermore, due to a large (unexplained) interindividual variability in paracetamol PK a relevant proportion of the fit older people remained either under- or over exposed.AIMSMETHODSRESULTSCONCLUSIONS

• All authors: Mian, P.; Esdonk, M.J. van; Olkkola, K.T.; Winter, B.C.M. de; Liukas, A.; Spriet, I.; Tibboel, D.; Petrovic, M.; Koch, B.C.P.; Allegaert, K.
• Date: 2018-10-15
• Volume: 85
• Issue: 1
• Pages: 126 - 135
• DOI: doi:10.1111/bcp.13770