Persistent URL of this record https://hdl.handle.net/1887/3201774
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Silencing anticoagulant protein c causes spontaneous atherothrombosis in ApoE knockout mice
Objectives: Studies on atherothrombosis, a major cause of cardiovascular
events, are hampered by the lack of animal models spontaneously developing
atherothrombosis. Major underlying problems are the stability of
the atherosclerotic plaques, combined with the strong plasma anticoagulant
activity. We hypothesized that inhibition of the anticoagulant system
by silencing of protein C (Proc) may cause murine atherosclerotic plaques
to become prone to atherothrombosis.
- All authors
- Ouweneel, A.B.; Heestermans, M.; Verwilligen, R.A.F.; Eck, M. van; Vlijmen, B.J.M. van
- Date
- 2016-09-30
- Volume
- 252
- Pages
- E26