Secondary-Structure-Driven Self-Assembly of Reactive Polypept(o)ides: Controlling Size, Shape, and Function of Core Cross-Linked Nanostructures

Klinker, K.; Schäfer, O.; Huesmann, D.; Bauer, T.; Capelôa, L.; Braun, L.; ... ; Barz, M. (2017)

Article / Letter to editor

Achieving precise control over the morphology and function of polymeric nanostructures during self-assembly remains a challenge in materials as well as biomedical science, especially when independent control over particle properties is desired. Herein, we report on nanostructures derived from amphiphilic block copolypept(o)ides by secondary-structure-directed self-assembly, presenting a strategy to adjust core polarity and function separately from particle preparation in a bioreversible manner. The peptide-inherent process of secondary-structure formation allows for the synthesis of spherical and worm-like core-cross-linked architectures from the same block copolymer, introducing a simple yet powerful approach to versatile peptide-based core-shell nanostructures.

• All authors: Klinker, K.; Schäfer, O.; Huesmann, D.; Bauer, T.; Capelôa, L.; Braun, L.; Stergiou, N.; Schinnerer, M.; Dirisala, A.; Miyata, K.; Osada, K.; Cabral, H.; Kataoka, K.; Barz, M.
• Date: 2017-09-01
• Volume: 56
• Issue: 32
• Pages: 9608 - 9613
• DOI: doi:10.1002/anie.201702624