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Bartneck, M.; Schlößer, C.T.; Barz, M.; Zentel, R.; Trautwein, C.; Lammers, T.; Tacke, F. (2017)

Immunomodulatory Therapy of Inflammatory Liver Disease Using Selectin-Binding Glycopolymers

Article / Letter to editor
) or Concanavalin A (ConA)-based hepatitis. Its sulfated counterpart, on the other hand, induced a decrease in infiltrating and resident macrophages, increased T helper cells, and aggravated immune-mediated liver injury. We demonstrate that, in the context of selectin-binding glycopolymers, minor modifications strongly impact leukocyte influx and macrophage activation, thereby ameliorating or aggravating liver inflammation depending on the underlying immunopathology. The nonsulfated random glycopolymer is a promising candidate for the treatment of inflammatory disease. The modulation of hepatic immune cells by selectin-binding glycopolymers might breach the immunosuppressive hepatic microenvironment and could improve efficacy of immunotherapies for inflammatory disease and cancer.
All authors
Bartneck, M.; Schlößer, C.T.; Barz, M.; Zentel, R.; Trautwein, C.; Lammers, T.; Tacke, F.
Date
2017-11-24
Volume
11
Issue
10
Pages
9689 - 9700
DOI
doi:10.1021/acsnano.7b04630